SLIK5_HUMAN » SLIT and NTRK-like protein 5

SLIK5_HUMAN » SLIT and NTRK-like protein 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLIK5_HUMAN » SLIT and NTRK-like protein 5 » Leucine-rich repeat-containing protein 11;
Hydrophobic Thickness 39.2 ± 4.8 Å
Tilt Angle 23 ± 9°
ΔGtransfer -35.4 kcal/mol
ΔGfold -28.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 661-689 (660-693)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 105-165, PDBID: 4Y61, Subunit B, Seq Identity:72%, Leucine rich repeat

AA: 129-189, PDBID: 1OZN, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 153-212, PDBID: 4RCA, Subunit B, Seq Identity:58%, Leucine rich repeat

AA: 412-469, PDBID: 1XCD, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 457-517, PDBID: 5CMN, Subunit B, Seq Identity:40%, Leucine rich repeat

UniProt annotation for SLIK5_HUMAN » SLIT and NTRK-like protein 5
FUNCTION: Suppresses neurite outgrowth.

TISSUE SPECIFICITY: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.

UniProt features for SLIK5_HUMAN » SLIT and NTRK-like protein 5
SIGNAL 1 40 Potential.
CHAIN 41 958 SLIT and NTRK-like protein 5.
REPEAT 82 103 LRR 1.
REPEAT 106 127 LRR 2.
REPEAT 130 151 LRR 3.
REPEAT 154 175 LRR 4.
REPEAT 178 199 LRR 5.
REPEAT 201 222 LRR 6.
DOMAIN 235 286 LRRCT 1.
DOMAIN 365 407 LRRNT.
REPEAT 410 431 LRR 7.
REPEAT 434 455 LRR 8.
REPEAT 458 479 LRR 9.
REPEAT 482 503 LRR 10.
REPEAT 506 527 LRR 11.
REPEAT 529 550 LRR 12.
DOMAIN 563 614 LRRCT 2.
Amino Acid Sequence for SLIK5_HUMAN » SLIT and NTRK-like protein 5
MHTCCPPVTL EQDLHRKMHS WMLQTLAFAV TSLVLSCAET IDYYGEICDN ACPCEEKDGI LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLNRLYPNE FVNYTGASIL HLGSNVIQDI ETGAFHGLRG LRRLHLNNNK LELLRDDTFL GLENLEYLQV DYNYISVIEP NAFGKLHLLQ VLILNDNLLS SLPNNLFRFV PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS CELISLKDWL DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRRLIS DYEMRPQTPL STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS KDLGYSNYGP SIAYQTKSPV PLECPTACSC NLQISDLGLN VNCQERKIES IAELQPKPYN PKKMYLTENY IAVVRRTDFL EATGLDLLHL GNNRISMIQD RAFGDLTNLR RLYLNGNRIE RLSPELFYGL QSLQYLFLQY NLIREIQSGT FDPVPNLQLL FLNNNLLQAM PSGVFSGLTL LRLNLRSNHF TSLPVSGVLD QLKSLIQIDL HDNPWDCTCD IVGMKLWVEQ LKVGVLVDEV ICKAPKKFAE TDMRSIKSEL LCPDYSDVVV STPTPSSIQV PARTSAVTPA VRLNSTGAPA SLGAGGGASS VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT STNNSDVSSF NMQYSVYGGG GGTGGHPHAH VHHRGPALPK VKTPAGHVYE YIPHPLGHMC KNPIYRSREG NSVEDYKDLH ELKVTYSSNH HLQQQQQPPP PPQQPQQQPP PQLQLQPGEE ERRESHHLRS PAYSVSTIEP REDLLSPVQD ADRFYRGILE PDKHCSTTPA GNSLPEYPKF PCSPAAYTFS PNYDLRRPHQ YLHPGAGDSR LREPVLYSPP SAVFVEPNRN EYLELKAKLN VEPDYLEVLE KQTTFSQF