SLIK4_HUMAN » SLIT and NTRK-like protein 4

SLIK4_HUMAN » SLIT and NTRK-like protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLIK4_HUMAN » SLIT and NTRK-like protein 4 »
Hydrophobic Thickness 40.4 ± 4.4 Å
Tilt Angle 24 ± 15°
ΔGtransfer -36.8 kcal/mol
ΔGfold -30.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 616-644 (616-647)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 83-143, PDBID: 4Y61, Subunit B, Seq Identity:73%, Leucine rich repeat

AA: 139-190, PDBID: 4Y61, Subunit B, Seq Identity:66%, Leucine rich repeat

AA: 429-485, PDBID: 1XCD, Subunit A, Seq Identity:40%, Leucine rich repeat

UniProt annotation for SLIK4_HUMAN » SLIT and NTRK-like protein 4
FUNCTION: Suppresses neurite outgrowth.

TISSUE SPECIFICITY: Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors.

UniProt features for SLIK4_HUMAN » SLIT and NTRK-like protein 4
SIGNAL 1 18 Potential.
CHAIN 19 837 SLIT and NTRK-like protein 4.
REPEAT 60 81 LRR 1.
REPEAT 84 105 LRR 2.
REPEAT 108 129 LRR 3.
REPEAT 132 153 LRR 4.
REPEAT 156 177 LRR 5.
REPEAT 179 200 LRR 6.
DOMAIN 213 264 LRRCT 1.
DOMAIN 333 375 LRRNT.
REPEAT 378 399 LRR 7.
REPEAT 402 423 LRR 8.
REPEAT 426 447 LRR 9.
REPEAT 450 471 LRR 10.
REPEAT 474 495 LRR 11.
REPEAT 497 518 LRR 12.
DOMAIN 531 582 LRRCT 2.
Amino Acid Sequence for SLIK4_HUMAN » SLIT and NTRK-like protein 4
MFLWLFLILS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR PNQLKPPWSN FYHLNFQNNF LNILYPNTFL NFSHAVSLHL GNNKLQNIEG GAFLGLSALK QLHLNNNELK ILRADTFLGI ENLEYLQADY NLIKYIERGA FNKLHKLKVL ILNDNLISFL PDNIFRFASL THLDIRGNRI QKLPYIGVLE HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA ICETPSDLYG RLLKETNKQE LCPMGTGSDF DVRILPPSQL ENGYTTPNGH TTQTSLHRLV TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPAPCFCKT HPSDLGLSVN CQEKNIQSMS ELIPKPLNAK KLHVNGNSIK DVDVSDFTDF EGLDLLHLGS NQITVIKGDV FHNLTNLRRL YLNGNQIERL YPEIFSGLHN LQYLYLEYNL IKEISAGTFD SMPNLQLLYL NNNLLKSLPV YIFSGAPLAR LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV ALKLWVEKLS DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITF TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT VKHEGLGNPD CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC GLKESETGFM FSDPPGQKVV MRNVADKEKD LLHVDTRKRL STIDELDELF PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR YPEKQPDKKS KKSLIGGNHS KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKI