SLIK3_HUMAN » SLIT and NTRK-like protein 3

SLIK3_HUMAN » SLIT and NTRK-like protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLIK3_HUMAN » SLIT and NTRK-like protein 3 »
Hydrophobic Thickness 37.6 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -54.4 kcal/mol
ΔGfold -26.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 650-679 (650-684)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 432-492, PDBID: 4Y61, Subunit B, Seq Identity:42%, Leucine rich repeat

AA: 456-516, PDBID: 4LI1, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 480-539, PDBID: 4RCA, Subunit B, Seq Identity:42%, Leucine rich repeat

UniProt annotation for SLIK3_HUMAN » SLIT and NTRK-like protein 3
FUNCTION: Suppresses neurite outgrowth.

TISSUE SPECIFICITY: Expressed in the occipital lobe of the cerebral cortex of the brain. Expressed at higher levels in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.

UniProt features for SLIK3_HUMAN » SLIT and NTRK-like protein 3
SIGNAL 1 26 Potential.
CHAIN 27 977 SLIT and NTRK-like protein 3.
REPEAT 78 99 LRR 1.
REPEAT 102 123 LRR 2.
REPEAT 126 147 LRR 3.
REPEAT 150 171 LRR 4.
REPEAT 174 195 LRR 5.
REPEAT 197 218 LRR 6.
DOMAIN 232 283 LRRCT 1.
DOMAIN 364 406 LRRNT.
REPEAT 409 430 LRR 7.
REPEAT 433 454 LRR 8.
REPEAT 457 478 LRR 9.
REPEAT 481 502 LRR 10.
REPEAT 505 526 LRR 11.
REPEAT 528 549 LRR 12.
DOMAIN 562 613 LRRCT 2.
Amino Acid Sequence for SLIK3_HUMAN » SLIT and NTRK-like protein 3
MKPSIAEMLH RGRMLWIILL STIALGWTTP IPLIEDSEEI DEPCFDPCYC EVKESLFHIH CDSKGFTNIS QITEFWSRPF KLYLQRNSMR KLYTNSFLHL NNAVSINLGN NALQDIQTGA FNGLKILKRL YLHENKLDVF RNDTFLGLES LEYLQADYNV IKRIESGAFR NLSKLRVLIL NDNLIPMLPT NLFKAVSLTH LDLRGNRLKV LFYRGMLDHI GRSLMELQLE ENPWNCTCEI VQLKSWLERI PYTALVGDIT CETPFHFHGK DLREIRKTEL CPLLSDSEVE ASLGIPHSSS SKENAWPTKP SSMLSSVHFT ASSVEYKSSN KQPKPTKQPR TPRPPSTSQA LYPGPNQPPI APYQTRPPIP IICPTGCTCN LHINDLGLTV NCKERGFNNI SELLPRPLNA KKLYLSSNLI QKIYRSDFWN FSSLDLLHLG NNRISYVQDG AFINLPNLKS LFLNGNDIEK LTPGMFRGLQ SLHYLYFEFN VIREIQPAAF SLMPNLKLLF LNNNLLRTLP TDAFAGTSLA RLNLRKNYFL YLPVAGVLEH LNAIVQIDLN ENPWDCTCDL VPFKQWIETI SSVSVVGDVL CRSPENLTHR DVRTIELEVL CPEMLHVAPA GESPAQPGDS HLIGAPTSAS PYEFSPPGGP VPLSVLILSL LVLFFSAVFV AAGLFAYVLR RRRKKLPFRS KRQEGVDLTG IQMQCHRLFE DGGGGGGGSG GGGRPTLSSP EKAPPVGHVY EYIPHPVTQM CNNPIYKPRE EEEVAVSSAQ EAGSAERGGP GTQPPGMGEA LLGSEQFAET PKENHSNYRT LLEKEKEWAL AVSSSQLNTI VTVNHHHPHH PAVGGVSGVV GGTGGDLAGF RHHEKNGGVV LFPPGGGCGS GSMLLDRERP QPAPCTVGFV DCLYGTVPKL KELHVHPPGM QYPDLQQDAR LKETLLFSAG KGFTDHQTQK SDYLELRAKL QTKPDYLEVL EKTTYRF