SLIK2_HUMAN » SLIT and NTRK-like protein 2

SLIK2_HUMAN » SLIT and NTRK-like protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLIK2_HUMAN » SLIT and NTRK-like protein 2 »
Hydrophobic Thickness 37.6 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -53.1 kcal/mol
ΔGfold -24.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 617-648 (617-648)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 86-146, PDBID: 4Y61, Subunit B, Seq Identity:96%, Leucine rich repeat

AA: 142-193, PDBID: 4Y61, Subunit B, Seq Identity:98%, Leucine rich repeat

AA: 399-459, PDBID: 4Y61, Subunit B, Seq Identity:50%, Leucine rich repeat

UniProt annotation for SLIK2_HUMAN » SLIT and NTRK-like protein 2
FUNCTION: Suppresses neurite outgrowth.

TISSUE SPECIFICITY: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.

UniProt features for SLIK2_HUMAN » SLIT and NTRK-like protein 2
SIGNAL 1 21 Potential.
CHAIN 22 845 SLIT and NTRK-like protein 2.
REPEAT 63 84 LRR 1.
REPEAT 87 108 LRR 2.
REPEAT 111 132 LRR 3.
REPEAT 135 156 LRR 4.
REPEAT 159 180 LRR 5.
REPEAT 182 203 LRR 6.
DOMAIN 216 265 LRRCT 1.
DOMAIN 331 373 LRRNT.
REPEAT 376 397 LRR 7.
REPEAT 400 421 LRR 8.
REPEAT 424 445 LRR 9.
REPEAT 448 469 LRR 10.
REPEAT 472 493 LRR 11.
REPEAT 495 516 LRR 12.
DOMAIN 529 580 LRRCT 2.
Amino Acid Sequence for SLIK2_HUMAN » SLIT and NTRK-like protein 2
MLSGVWFLSV LTVAGILQTE SRKTAKDICK IRCLCEEKEN VLNINCENKG FTTVSLLQPP QYRIYQLFLN GNLLTRLYPN EFVNYSNAVT LHLGNNGLQE IRTGAFSGLK TLKRLHLNNN KLEILREDTF LGLESLEYLQ ADYNYISAIE AGAFSKLNKL KVLILNDNLL LSLPSNVFRF VLLTHLDLRG NRLKVMPFAG VLEHIGGIME IQLEENPWNC TCDLLPLKAW LDTITVFVGE IVCETPFRLH GKDVTQLTRQ DLCPRKSASD SSQRGSHADT HVQRLSPTMN PALNPTRAPK ASRPPKMRNR PTPRVTVSKD RQSFGPIMVY QTKSPVPLTC PSSCVCTSQS SDNGLNVNCQ ERKFTNISDL QPKPTSPKKL YLTGNYLQTV YKNDLLEYSS LDLLHLGNNR IAVIQEGAFT NLTSLRRLYL NGNYLEVLYP SMFDGLQSLQ YLYLEYNVIK EIKPLTFDAL INLQLLFLNN NLLRSLPDNI FGGTALTRLN LRNNHFSHLP VKGVLDQLPA FIQIDLQENP WDCTCDIMGL KDWTEHANSP VIINEVTCES PAKHAGEILK FLGREAICPD SPNLSDGTVL SMNHNTDTPR SLSVSPSSYP ELHTEVPLSV LILGLLVVFI LSVCFGAGLF VFVLKRRKGV PSVPRNTNNL DVSSFQLQYG SYNTETHDKT DGHVYNYIPP PVGQMCQNPI YMQKEGDPVA YYRNLQEFSY SNLEEKKEEP ATPAYTISAT ELLEKQATPR EPELLYQNIA ERVKELPSAG LVHYNFCTLP KRQFAPSYES RRQNQDRINK TVLYGTPRKC FVGQSKPNHP LLQAKPQSEP DYLEVLEKQT AISQL