SLIK1_HUMAN » SLIT and NTRK-like protein 1

SLIK1_HUMAN » SLIT and NTRK-like protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLIK1_HUMAN » SLIT and NTRK-like protein 1 » Leucine-rich repeat-containing protein 12;
Hydrophobic Thickness 41.2 ± 4.0 Å
Tilt Angle 1 ± 13°
ΔGtransfer -34.8 kcal/mol
ΔGfold -21.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 615-643 (611-647)
Pathways none
PDB 4rcw (341-580), 4rca (B=20-264)
OPM none
Complexes

PTPRD:SLIK1_HUMAN

Interactions

PTPRD, Complex: PTPRD:SLIK1, PDBID: 4RCA

Domains

AA: 82-142, PDBID: 4RCA, Subunit B, Seq Identity:100%, Leucine rich repeat

AA: 132-189, PDBID: 4RCA, Subunit B, Seq Identity:100%, Leucine rich repeat

UniProt annotation for SLIK1_HUMAN » SLIT and NTRK-like protein 1
FUNCTION: Enhances neuronal dendrite outgrowth.

TISSUE SPECIFICITY: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.

DEVELOPMENTAL STAGE: At 20 weeks of gestation, expressed in multiple brain regions, including the developing neo-cortical plate, subplate zone, striatum, globus pallidus, thalamus and subthalamus.

DISEASE: Gilles de la Tourette syndrome (GTS) OMIM: Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. mutations affecting the gene represented in this entry.

DISEASE: Trichotillomania (TTM) OMIM: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. Note=The disease may be caused by mutations affecting the gene represented in this entry.

UniProt features for SLIK1_HUMAN » SLIT and NTRK-like protein 1
SIGNAL 1 17 Potential.
CHAIN 18 696 SLIT and NTRK-like protein 1.
DOMAIN 18 57 LRRNT 1.
REPEAT 59 80 LRR 1.
REPEAT 83 104 LRR 2.
REPEAT 106 128 LRR 3.
REPEAT 131 152 LRR 4.
REPEAT 155 176 LRR 5.
REPEAT 178 199 LRR 6.
DOMAIN 212 263 LRRCT 1.
DOMAIN 332 373 LRRNT 2.
REPEAT 376 397 LRR 7.
REPEAT 400 421 LRR 8.
REPEAT 424 445 LRR 9.
REPEAT 448 469 LRR 10.
REPEAT 472 493 LRR 11.
REPEAT 495 516 LRR 12.
DOMAIN 529 580 LRRCT 2.
Amino Acid Sequence for SLIK1_HUMAN » SLIT and NTRK-like protein 1
MLLWILLLET SLCFAAGNVT GDVCKEKICS CNEIEGDLHV DCEKKGFTSL QRFTAPTSQF YHLFLHGNSL TRLFPNEFAN FYNAVSLHME NNGLHEIVPG AFLGLQLVKR LHINNNKIKS FRKQTFLGLD DLEYLQADFN LLRDIDPGAF QDLNKLEVLI LNDNLISTLP ANVFQYVPIT HLDLRGNRLK TLPYEEVLEQ IPGIAEILLE DNPWDCTCDL LSLKEWLENI PKNALIGRVV CEAPTRLQGK DLNETTEQDL CPLKNRVDSS LPAPPAQEET FAPGPLPTPF KTNGQEDHAT PGSAPNGGTK IPGNWQIKIR PTAAIATGSS RNKPLANSLP CPGGCSCDHI PGSGLKMNCN NRNVSSLADL KPKLSNVQEL FLRDNKIHSI RKSHFVDYKN LILLDLGNNN IATVENNTFK NLLDLRWLYM DSNYLDTLSR EKFAGLQNLE YLNVEYNAIQ LILPGTFNAM PKLRILILNN NLLRSLPVDV FAGVSLSKLS LHNNYFMYLP VAGVLDQLTS IIQIDLHGNP WECSCTIVPF KQWAERLGSE VLMSDLKCET PVNFFRKDFM LLSNDEICPQ LYARISPTLT SHSKNSTGLA ETGTHSNSYL DTSRVSISVL VPGLLLVFVT SAFTVVGMLV FILRNRKRSK RRDANSSASE INSLQTVCDS SYWHNGPYNA DGAHRVYDCG SHSLSD