SLG1_YEAST » Protein SLG1

SLG1_YEAST » Protein SLG1
Magnify SLG1_YEAST » Protein SLG1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLG1_YEAST » Protein SLG1 » Cell wall integrity and stress response component 1;Synthetic lethal with GAP protein 1;
Hydrophobic Thickness 37.6 ± 1.8 Å
Tilt Angle 12 ± 4°
ΔGtransfer -40.4 kcal/mol
ΔGfold -14.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 262-291 (262-293)
Pathways

MAPK signaling pathway - yeast (KEGG)

PDB none
OPM none
Complexes none
Interactions

ERG2, Complex: ERG2:SLG1

MID2, Complex: MID2:SLG1, PubMed

MMM1, Complex: SLG1:MMM1

TOM70, Complex: TOM70:SLG1, PubMed

UBX2, Complex: SLG1:UBX2

WSC2, Complex: SLG1:WSC2

WSC3, Complex: SLG1:WSC3

WSC4, Complex: SLG1:WSC4

Domains

AA: 24-100, WSC domain

UniProt annotation for SLG1_YEAST » Protein SLG1
FUNCTION: Plays a role during G1 to regulate entering or exiting the cell cycle. Involved in stress responses. Has a role in cell wall integrity signaling. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1. Important regulator of the actin cytoskeleton rearrangements in conditions of cell wall expansion and membrane stretching. Specifically required for the actin reorganization induced by hypo-osmotic shock. Multicopy suppressor of 1,3-beta-glucan synthase (GS). Activates GS upstream of RHO1. Acts positively on the PKC1-MAPK pathway. Activates transiently SLT2 during alkaline stress, which leads to an increase in the expression of several specific genes.

MISCELLANEOUS: Present with 664 molecules/cell in log phase SD medium.

UniProt features for SLG1_YEAST » Protein SLG1
SIGNAL 1 21 Potential.
CHAIN 22 378 Protein SLG1.
DOMAIN 22 110 WSC.
Amino Acid Sequence for SLG1_YEAST » Protein SLG1
MRPNKTSLLL ALLSILSQAN AYEYVNCFSS LPSDFSKADS YNWQSSSHCN SECSAKGASY FALYNHSECY CGDTNPSGSE STSSSCNTYC FGYSSEMCGG EDAYSVYQLD SDTNSNSISS SDSSTESTSA SSSTTSSTTS STTSTTSSTT SSTTSSMASS STVQNSPEST QAAASISTSQ SSSTVTSESS LTSDTLATSS TSSQSQDATS IIYSTTFHTE GGSTIFVTNT ITASAQNSGS ATGTAGSDST SGSKTHKKKA NVGAIVGGVV GGVVGAVAIA LCILLIVRHI NMKREQDRME KEYQEAIKPV EYPDKLYASS FSSNHGPSSG SFEEEHTKGQ TDINPFDDSR RISNGTFING GPGGKNNVLT VVNPDEAD