SLAF8_HUMAN » SLAM family member 8

SLAF8_HUMAN » SLAM family member 8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLAF8_HUMAN » SLAM family member 8 » B-lymphocyte activator macrophage expressed;BCM-like membrane protein;
Hydrophobic Thickness 34.0 ± 1.6 Å
Tilt Angle 3 ± 2°
ΔGtransfer -44.2 kcal/mol
ΔGfold -14.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 230-257 (229-257)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 127-205, Immunoglobulin domain

UniProt annotation for SLAF8_HUMAN » SLAM family member 8
FUNCTION: May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

TISSUE SPECIFICITY: Expressed in lymph node, spleen, thymus and bone marrow.

UniProt features for SLAF8_HUMAN » SLAM family member 8
SIGNAL 1 22
CHAIN 23 285 SLAM family member 8.
DOMAIN 128 215 Ig-like C2-type.
DISULFID 152 201 By similarity.
Amino Acid Sequence for SLAF8_HUMAN » SLAM family member 8
MVMRPLWSLL LWEALLPITV TGAQVLSKVG GSVLLVAARP PGFQVREAIW RSLWPSEELL ATFFRGSLET LYHSRFLGRA QLHSNLSLEL GPLESGDSGN FSVLMVDTRG QPWTQTLQLK VYDAVPRPVV QVFIAVERDA QPSKTCQVFL SCWAPNISEI TYSWRRETTM DFGMEPHSLF TDGQVLSISL GPGDRDVAYS CIVSNPVSWD LATVTPWDSC HHEAAPGKAS YKDVLLVVVP VSLLLMLVTL FSAWHWCPCS GKKKKDVHAD RVGPETENPL VQDLP