SLAF6_HUMAN » SLAM family member 6

SLAF6_HUMAN » SLAM family member 6
Magnify SLAF6_HUMAN » SLAM family member 6Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLAF6_HUMAN » SLAM family member 6 » Activating NK receptor;NK-T-B-antigen;NTB-A;
Hydrophobic Thickness 35.2 ± 1.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -49.0 kcal/mol
ΔGfold -23.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 223-250 (221-252)
Pathways none
PDB 2if7 (A/B/C/D=24-215)
OPM 2if7
Complexes

SLAF6:SLAF6_HUMAN

Interactions

SLAF6, Complex: Homodimer of SLAM family member 6, PDBID: 2IF7

Domains

AA: 26-127, PDBID: 2IF7, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for SLAF6_HUMAN » SLAM family member 6
FUNCTION: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.

SUBUNIT: Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP.

TISSUE SPECIFICITY: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes.

UniProt features for SLAF6_HUMAN » SLAM family member 6
SIGNAL 1 21
CHAIN 22 332 SLAM family member 6.
DOMAIN 132 209 Ig-like.
DISULFID 147 214
DISULFID 153 195
Amino Acid Sequence for SLAF6_HUMAN » SLAM family member 6
MLWLFQSLLF VFCFGPGNVV SQSSLTPLMV NGILGESVTL PLEFPAGEKV NFITWLFNET SLAFIVPHET KSPEIHVTNP KQGKRLNFTQ SYSLQLSNLK MEDTGSYRAQ ISTKTSAKLS SYTLRILRQL RNIQVTNHSQ LFQNMTCELH LTCSVEDADD NVSFRWEALG NTLSSQPNLT VSWDPRISSE QDYTCIAENA VSNLSFSVSA QKLCEDVKIQ YTDTKMILFM VSGICIVFGF IILLLLVLRK RRDSLSLSTQ RTQGPAESAR NLEYVSVSPT NNTVYASVTH SNRETEIWTP RENDTITIYS TINHSKESKP TFSRATALDN VV