SLAF5_HUMAN » SLAM family member 5

SLAF5_HUMAN » SLAM family member 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLAF5_HUMAN » SLAM family member 5 » Cell surface antigen MAX.3;Hly9-beta;Leukocyte differentiation antigen CD84;Signaling lymphocytic activation molecule 5;
Hydrophobic Thickness 34.8 ± 2.4 Å
Tilt Angle 2 ± 1°
ΔGtransfer -44.7 kcal/mol
ΔGfold -23.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 225-249 (223-253)
Pathways

Hemostasis (Reactome)

PDB 2pkd (A/B...=22-131)
OPM none
Complexes

SLAF5:SLAF5_HUMAN

Interactions

SLAF5, Complex: Homodimer of SLAM family member 5, PDBID: 2PKD

Domains

AA: 134-197, PDBID: 2if7, Subunit A, Seq Identity:33%, Immunoglobulin domain

UniProt annotation for SLAF5_HUMAN » SLAM family member 5
FUNCTION: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.

SUBUNIT: Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A.

TISSUE SPECIFICITY: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells.

DEVELOPMENTAL STAGE: Expression is slightly increased in naive B- cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.

DOMAIN: ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A.

UniProt features for SLAF5_HUMAN » SLAM family member 5
SIGNAL 1 21
CHAIN 22 345 SLAM family member 5.
DOMAIN 135 207 Ig-like C2-type.
MOTIF 277 282 ITSM motif 1.
MOTIF 314 319 ITSM motif 2.
DISULFID 155 193 By similarity.
Amino Acid Sequence for SLAF5_HUMAN » SLAM family member 5
MAQHHLWILL LCLQTWPEAA GKDSEIFTVN GILGESVTFP VNIQEPRQVK IIAWTSKTSV AYVTPGDSET APVVTVTHRN YYERIHALGP NYNLVISDLR MEDAGDYKAD INTQADPYTT TKRYNLQIYR RLGKPKITQS LMASVNSTCN VTLTCSVEKE EKNVTYNWSP LGEEGNVLQI FQTPEDQELT YTCTAQNPVS NNSDSISARQ LCADIAMGFR THHTGLLSVL AMFFLLVLIL SSVFLFRLFK RRQGRIFPEG SCLNTFTKNP YAASKKTIYT YIMASRNTQP AESRIYDEIL QSKVLPSKEE PVNTVYSEVQ FADKMGKAST QDSKPPGTSS YEIVI