SLAF1_HUMAN » Signaling lymphocytic activation molecule

SLAF1_HUMAN » Signaling lymphocytic activation molecule
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLAF1_HUMAN » Signaling lymphocytic activation molecule » CDw150;IPO-3;
Hydrophobic Thickness 32.4 ± 1.6 Å
Tilt Angle 0 ± 1°
ΔGtransfer -39.3 kcal/mol
ΔGfold -18.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 238-261 (237-263)
Pathways

Measles (KEGG)

PDB 1i3z (B=273-286), 1ka7 (B=275-286), 1ka6 (B=276-282), 1d4t (B=276-286), 1m27 (B=276-286), 1d4w (C/D=276-286)
OPM none
Complexes none
Interactions

PTPRC, Complex: PTPRC:SLAF1, PubMed

Domains

AA: 1-125, Signaling lymphocytic activation molecule (SLAM) protein

UniProt annotation for SLAF1_HUMAN » Signaling lymphocytic activation molecule
FUNCTION: High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

SUBUNIT: Interacts (via cytoplasmic domain) with SH2D1A, SH2D1B and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus H protein and acts as a receptor for this virus.

TISSUE SPECIFICITY: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.

DOMAIN: The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.

UniProt features for SLAF1_HUMAN » Signaling lymphocytic activation molecule
SIGNAL 1 20 Potential.
CHAIN 21 335 Signaling lymphocytic activation molecule.
DOMAIN 144 223 Ig-like C2-type.
DOMAIN ? 152 Ig-like V-type.
MOTIF 281 286 SH2-binding (Potential).
MOTIF 307 312 SH2-binding (Potential).
MOTIF 327 332 SH2-binding (Potential).
DISULFID 158 228 By similarity.
DISULFID 164 209 By similarity.
Amino Acid Sequence for SLAF1_HUMAN » Signaling lymphocytic activation molecule
MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV YAGLLGGVIM ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES