SIT1_HUMAN » Signaling threshold-regulating transmembrane adapter 1

SIT1_HUMAN » Signaling threshold-regulating transmembrane adapter 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIT1_HUMAN » Signaling threshold-regulating transmembrane adapter 1 » SHP2-interacting transmembrane adapter protein;Suppression-inducing transmembrane adapter 1;gp30/40;
Hydrophobic Thickness 32.0 ± 5.0 Å
Tilt Angle 10 ± 2°
ΔGtransfer -42.2 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 39-64 (35-70)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 45-138, SHP2-interacting transmembrane adaptor protein, SIT

UniProt annotation for SIT1_HUMAN » Signaling threshold-regulating transmembrane adapter 1
FUNCTION: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells.

SUBUNIT: Homodimer; disulfide-linked. When phosphorylated, interacts with PTPN11/SHP2, GRB2 and CSK.

TISSUE SPECIFICITY: Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma.

UniProt features for SIT1_HUMAN » Signaling threshold-regulating transmembrane adapter 1
SIGNAL 1 24 Potential.
CHAIN 25 196 Signaling threshold-regulating transmembrane adapter 1.
REGION 90 93 Interaction with GRB2.
REGION 146 151 Interaction with PTPN11.
REGION 169 172 Interaction with CSK.
REGION 188 191 Interaction with GRB2.
DISULFID 27 27 Interchain (Probable).
Amino Acid Sequence for SIT1_HUMAN » Signaling threshold-regulating transmembrane adapter 1
MNQADPRLRA VCLWTLTSAA MSRGDNCTDL LALGIPSITQ AWGLWVLLGA VTLLFLISLA AHLSQWTRGR SRSHPGQGRS GESVEEVPLY GNLHYLQTGR LSQDPEPDQQ DPTLGGPARA AEEVMCYTSL QLRPPQGRIP GPGTPVKYSE VVLDSEPKSQ ASGPEPELYA SVCAQTRRAR ASFPDQAYAN SQPAAS