SIRPG_HUMAN » Signal-regulatory protein gamma

SIRPG_HUMAN » Signal-regulatory protein gamma
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIRPG_HUMAN » Signal-regulatory protein gamma » SIRP-gamma; CD172 antigen-like family member B;Signal-regulatory protein beta-2;SIRP-b2; SIRP-beta-2;
Hydrophobic Thickness 24.8 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -28.9 kcal/mol
ΔGfold -12.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 362-386 (362-386)
Pathways

Cell-Cell communication (Reactome)

Hemostasis (Reactome)

Osteoclast differentiation (KEGG)

PDB 2jjw (A=29-147), 4i2x (E/F=29-347)
OPM none
Complexes

SIRPG:SIRPG_HUMAN

Interactions

SIRPG, Complex: Homodimer of signal-regulatory protein gamma, PDBID: 4I2X

Domains

AA: 36-139, PDBID: 2JJW, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 146-233, PDBID: 4I2X, Subunit E, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 251-336, PDBID: 4I2X, Subunit E, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for SIRPG_HUMAN » Signal-regulatory protein gamma
FUNCTION: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

SUBUNIT: Interacts with CD47.

TISSUE SPECIFICITY: Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

UniProt features for SIRPG_HUMAN » Signal-regulatory protein gamma
SIGNAL 1 28 Potential.
CHAIN 29 387 Signal-regulatory protein gamma.
DOMAIN 29 137 Ig-like V-type.
DOMAIN 146 245 Ig-like C1-type 1.
DOMAIN 252 340 Ig-like C1-type 2.
DISULFID 53 119
DISULFID 168 226 Potential.
DISULFID 271 329 Potential.
Amino Acid Sequence for SIRPG_HUMAN » Signal-regulatory protein gamma
MPVPASWPHP PGPFLLLTLL LGLTEVAGEE ELQMIQPEKL LLVTVGKTAT LHCTVTSLLP VGPVLWFRGV GPGRELIYNQ KEGHFPRVTT VSDLTKRNNM DFSIRISSIT PADVGTYYCV KFRKGSPENV EFKSGPGTEM ALGAKPSAPV VLGPAARTTP EHTVSFTCES HGFSPRDITL KWFKNGNELS DFQTNVDPTG QSVAYSIRST ARVVLDPWDV RSQVICEVAH VTLQGDPLRG TANLSEAIRV PPTLEVTQQP MRVGNQVNVT CQVRKFYPQS LQLTWSENGN VCQRETASTL TENKDGTYNW TSWFLVNISD QRDDVVLTCQ VKHDGQLAVS KRLALEVTVH QKDQSSDATP GPASSLTALL LIAVLLGPIY VPWKQKT