SIRBL_HUMAN » Signal-regulatory protein beta-1 isoform 3

SIRBL_HUMAN » Signal-regulatory protein beta-1 isoform 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIRBL_HUMAN » Signal-regulatory protein beta-1 isoform 3 » SIRP-beta-1 isoform 3;
Hydrophobic Thickness 36.8 ± 5.0 Å
Tilt Angle 25 ± 4°
ΔGtransfer -28.9 kcal/mol
ΔGfold -15.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 367-393 (363-397)
Pathways

Osteoclast differentiation (KEGG)

PDB 2jjv (30-148)
OPM none
Complexes none
Interactions

SIRB1, Complex: SIRB1:SIRBL

Domains

AA: 37-144, PDBID: 2JJV, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 147-234, PDBID: 2WNG, Subunit A, Seq Identity:94%, Immunoglobulin C1-set domain

AA: 252-337, PDBID: 2WNG, Subunit A, Seq Identity:92%, Immunoglobulin C1-set domain

UniProt annotation for SIRBL_HUMAN » Signal-regulatory protein beta-1 isoform 3
FUNCTION: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.
UniProt features for SIRBL_HUMAN » Signal-regulatory protein beta-1 isoform 3
SIGNAL 1 29 Potential.
CHAIN 30 398 Signal-regulatory protein beta-1 isoform 3.
DOMAIN 31 136 Ig-like V-type 1.
DOMAIN 147 246 Ig-like C1-type 1.
DOMAIN 253 347 Ig-like C1-type 2.
DISULFID 54 120
DISULFID 169 227 By similarity.
DISULFID 272 330 By similarity.
Amino Acid Sequence for SIRBL_HUMAN » Signal-regulatory protein beta-1 isoform 3
MPVPASWPHL PSPFLLMTLL LGRLTGVAGE EELQVIQPDK SISVAAGESA TLHCTVTSLI PVGPIQWFRG AGPGRELIYN QKEGHFPRVT TVSDLTKRNN MDFSIRISNI TPADAGTYYC VKFRKGSPDH VEFKSGAGTE LSVRAKPSAP VVSGPAARAT PQHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDFQTNVDPA GDSVSYSIHS TAKVVLTRED VHSQVICEVA HVTLQGDPLR GTANLSETIR VPPTLEVTQQ PVRAENQVNV TCQVRKFYPQ RLQLTWLENG NVSRTETAST LTENKDGTYN WMSWLLVNVS AHRDDVKLTC QVEHDGQPAV SKSHDLKVSA HPKEQGSNTA PGPALASAAP LLIAFLLGPK VLLVVGVSVI YVYWKQKA