SIRB1_HUMAN » Signal-regulatory protein beta-1

SIRB1_HUMAN » Signal-regulatory protein beta-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIRB1_HUMAN » Signal-regulatory protein beta-1 » SIRP-beta-1; CD172 antigen-like family member B;
Hydrophobic Thickness 38.4 ± 1.2 Å
Tilt Angle 2 ± 1°
ΔGtransfer -28.2 kcal/mol
ΔGfold -10.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 368-393 (368-397)
Pathways

Cell-Cell communication (Reactome)

Immune System (Reactome)

Osteoclast differentiation (KEGG)

PDB 2jju (30-148), 2d9c (32-154)
OPM none
Complexes none
Interactions

SIRBL, Complex: SIRB1:SIRBL

TYOBP, Complex: SIRB1:TYOBP, PubMed

Domains

AA: 37-144, PDBID: 2D9C, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 147-234, PDBID: 4I2X, Subunit E, Seq Identity:77%, Immunoglobulin C1-set domain

AA: 252-337, PDBID: 2WNG, Subunit A, Seq Identity:82%, Immunoglobulin C1-set domain

UniProt annotation for SIRB1_HUMAN » Signal-regulatory protein beta-1
FUNCTION: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.

SUBUNIT: Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK.

TISSUE SPECIFICITY: Detected in monocytes and dendritic cells.

UniProt features for SIRB1_HUMAN » Signal-regulatory protein beta-1
SIGNAL 1 29 Potential.
CHAIN 30 398 Signal-regulatory protein beta-1.
DOMAIN 30 136 Ig-like V-type.
DOMAIN 147 246 Ig-like C1-type 1.
DOMAIN 253 347 Ig-like C1-type 2.
DISULFID 54 120
DISULFID 169 227 Potential.
DISULFID 320 320 Interchain.
Amino Acid Sequence for SIRB1_HUMAN » Signal-regulatory protein beta-1
MPVPASWPHL PSPFLLMTLL LGRLTGVAGE DELQVIQPEK SVSVAAGESA TLRCAMTSLI PVGPIMWFRG AGAGRELIYN QKEGHFPRVT TVSELTKRNN LDFSISISNI TPADAGTYYC VKFRKGSPDD VEFKSGAGTE LSVRAKPSAP VVSGPAVRAT PEHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDFQTNVDPA GDSVSYSIHS TARVVLTRGD VHSQVICEMA HITLQGDPLR GTANLSEAIR VPPTLEVTQQ PMRAENQANV TCQVSNFYPR GLQLTWLENG NVSRTETAST LIENKDGTYN WMSWLLVNTC AHRDDVVLTC QVEHDGQQAV SKSYALEISA HQKEHGSDIT HEAALAPTAP LLVALLLGPK LLLVVGVSAI YICWKQKA