SIGL9_HUMAN » Sialic acid-binding Ig-like lectin 9

SIGL9_HUMAN » Sialic acid-binding Ig-like lectin 9
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIGL9_HUMAN » Sialic acid-binding Ig-like lectin 9 » Siglec-9; CDw329;Protein FOAP-9;
Hydrophobic Thickness 27.6 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -30.0 kcal/mol
ΔGfold -12.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 352-373 (352-378)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 24-140, PDBID: 1NKO, Subunit A, Seq Identity:54%, Immunoglobulin V-set domain

UniProt annotation for SIGL9_HUMAN » Sialic acid-binding Ig-like lectin 9
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

TISSUE SPECIFICITY: Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for SIGL9_HUMAN » Sialic acid-binding Ig-like lectin 9
SIGNAL 1 17 Potential.
CHAIN 18 463 Sialic acid-binding Ig-like lectin 9.
DOMAIN 20 140 Ig-like V-type.
DOMAIN 146 229 Ig-like C2-type 1.
DOMAIN 236 336 Ig-like C2-type 2.
MOTIF 431 436 ITIM motif.
MOTIF 454 459 SLAM-like motif.
DISULFID 36 170 By similarity.
DISULFID 41 102 By similarity.
DISULFID 164 213 By similarity.
DISULFID 272 320 By similarity.
Amino Acid Sequence for SIGL9_HUMAN » Sialic acid-binding Ig-like lectin 9
MLLLLLPLLW GRERAEGQTS KLLTMQSSVT VQEGLCVHVP CSFSYPSHGW IYPGPVVHGY WFREGANTDQ DAPVATNNPA RAVWEETRDR FHLLGDPHTK NCTLSIRDAR RSDAGRYFFR MEKGSIKWNY KHHRLSVNVT ALTHRPNILI PGTLESGCPQ NLTCSVPWAC EQGTPPMISW IGTSVSPLDP STTRSSVLTL IPQPQDHGTS LTCQVTFPGA SVTTNKTVHL NVSYPPQNLT MTVFQGDGTV STVLGNGSSL SLPEGQSLRL VCAVDAVDSN PPARLSLSWR GLTLCPSQPS NPGVLELPWV HLRDAAEFTC RAQNPLGSQQ VYLNVSLQSK ATSGVTQGVV GGAGATALVF LSFCVIFVVV RSCRKKSARP AAGVGDTGIE DANAVRGSAS QGPLTEPWAE DSPPDQPPPA SARSSVGEGE LQYASLSFQM VKPWDSRGQE ATDTEYSEIK IHR