SIGL8_HUMAN » Sialic acid-binding Ig-like lectin 8

SIGL8_HUMAN » Sialic acid-binding Ig-like lectin 8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIGL8_HUMAN » Sialic acid-binding Ig-like lectin 8 » Siglec-8; Sialoadhesin family member 2;SAF-2;
Hydrophobic Thickness 38.8 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -40.0 kcal/mol
ΔGfold -17.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 365-387 (358-392)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-147, PDBID: 1NKO, Subunit A, Seq Identity:49%, Immunoglobulin V-set domain

AA: 265-332, PDBID: 3K0W, Subunit A, Seq Identity:35%, Immunoglobulin domain

UniProt annotation for SIGL8_HUMAN » Sialic acid-binding Ig-like lectin 8
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

TISSUE SPECIFICITY: Expressed specifically on eosinophils.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for SIGL8_HUMAN » Sialic acid-binding Ig-like lectin 8
SIGNAL 1 16 Potential.
CHAIN 17 499 Sialic acid-binding Ig-like lectin 8.
DOMAIN 40 123 Ig-like V-type.
DOMAIN 157 240 Ig-like C2-type 1.
DOMAIN 246 344 Ig-like C2-type 2.
MOTIF 445 450 ITIM motif.
MOTIF 468 473 SLAM-like motif.
DISULFID 42 181 By similarity.
DISULFID 47 107 By similarity.
DISULFID 175 224 By similarity.
DISULFID 283 328 By similarity.
Amino Acid Sequence for SIGL8_HUMAN » Sialic acid-binding Ig-like lectin 8
MLLLLLLLPL LWGTKGMEGD RQYGDGYLLQ VQELVTVQEG LCVHVPCSFS YPQDGWTDSD PVHGYWFRAG DRPYQDAPVA TNNPDREVQA ETQGRFQLLG DIWSNDCSLS IRDARKRDKG SYFFRLERGS MKWSYKSQLN YKTKQLSVFV TALTHRPDIL ILGTLESGHS RNLTCSVPWA CKQGTPPMIS WIGASVSSPG PTTARSSVLT LTPKPQDHGT SLTCQVTLPG TGVTTTSTVR LDVSYPPWNL TMTVFQGDAT ASTALGNGSS LSVLEGQSLR LVCAVNSNPP ARLSWTRGSL TLCPSRSSNP GLLELPRVHV RDEGEFTCRA QNAQGSQHIS LSLSLQNEGT GTSRPVSQVT LAAVGGAGAT ALAFLSFCII FIIVRSCRKK SARPAAGVGD TGMEDAKAIR GSASQGPLTE SWKDGNPLKK PPPAVAPSSG EEGELHYATL SFHKVKPQDP QGQEATDSEY SEIKIHKRET AETQACLRNH NPSSKEVRG