SIGL7_HUMAN » Sialic acid-binding Ig-like lectin 7

SIGL7_HUMAN » Sialic acid-binding Ig-like lectin 7
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIGL7_HUMAN » Sialic acid-binding Ig-like lectin 7 » Siglec-7; Adhesion inhibitory receptor molecule 1;AIRM-1; CDw328;D-siglec;QA79 membrane protein;p75;
Hydrophobic Thickness 37.6 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.1 kcal/mol
ΔGfold -14.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 357-379 (350-384)
Pathways none
PDB 1o7s (18-144), 1o7v (18-144), 2df3 (18-144), 2g5r (18-144), 2hrl (18-144), 1nko (19-150)
OPM none
Complexes none
Interactions none
Domains

AA: 29-146, PDBID: 1NKO, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 257-338, PDBID: 2ENS, Subunit A, Seq Identity:23%, Immunoglobulin domain

UniProt annotation for SIGL7_HUMAN » Sialic acid-binding Ig-like lectin 7
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

SUBUNIT: Interacts with PTPN6/SHP-1 upon phosphorylation.

TISSUE SPECIFICITY: Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for SIGL7_HUMAN » Sialic acid-binding Ig-like lectin 7
SIGNAL 1 18 Potential.
CHAIN 19 467 Sialic acid-binding Ig-like lectin 7.
DOMAIN 39 122 Ig-like V-type.
DOMAIN 150 233 Ig-like C2-type 1.
DOMAIN 240 336 Ig-like C2-type 2.
MOTIF 435 440 ITIM motif.
DISULFID 46 106
DISULFID 168 217 By similarity.
DISULFID 276 320 By similarity.
Amino Acid Sequence for SIGL7_HUMAN » Sialic acid-binding Ig-like lectin 7
MLLLLLLPLL WGRERVEGQK SNRKDYSLTM QSSVTVQEGM CVHVRCSFSY PVDSQTDSDP VHGYWFRAGN DISWKAPVAT NNPAWAVQEE TRDRFHLLGD PQTKNCTLSI RDARMSDAGR YFFRMEKGNI KWNYKYDQLS VNVTALTHRP NILIPGTLES GCFQNLTCSV PWACEQGTPP MISWMGTSVS PLHPSTTRSS VLTLIPQPQH HGTSLTCQVT LPGAGVTTNR TIQLNVSYPP QNLTVTVFQG EGTASTALGN SSSLSVLEGQ SLRLVCAVDS NPPARLSWTW RSLTLYPSQP SNPLVLELQV HLGDEGEFTC RAQNSLGSQH VSLNLSLQQE YTGKMRPVSG VLLGAVGGAG ATALVFLSFC VIFIVVRSCR KKSARPAADV GDIGMKDANT IRGSASQGNL TESWADDNPR HHGLAAHSSG EEREIQYAPL SFHKGEPQDL SGQEATNNEY SEIKIPK