SIGL6_HUMAN » Sialic acid-binding Ig-like lectin 6

SIGL6_HUMAN » Sialic acid-binding Ig-like lectin 6
Magnify SIGL6_HUMAN » Sialic acid-binding Ig-like lectin 6Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIGL6_HUMAN » Sialic acid-binding Ig-like lectin 6 » Siglec-6; CD33 antigen-like 1;CDw327;Obesity-binding protein 1;OB-BP1;
Hydrophobic Thickness 27.2 ± 3.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -39.5 kcal/mol
ΔGfold -13.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 352-374 (347-375)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 34-142, PDBID: 2ZG1, Subunit A, Seq Identity:41%, Immunoglobulin V-set domain

AA: 150-230, PDBID: 3JZ7, Subunit A, Seq Identity:25%, Immunoglobulin domain

AA: 253-336, PDBID: 3S97, Subunit D, Seq Identity:28%, Immunoglobulin I-set domain

UniProt annotation for SIGL6_HUMAN » Sialic acid-binding Ig-like lectin 6
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

SUBUNIT: Interacts with LEP.

TISSUE SPECIFICITY: Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for SIGL6_HUMAN » Sialic acid-binding Ig-like lectin 6
SIGNAL 1 26 Potential.
CHAIN 27 453 Sialic acid-binding Ig-like lectin 6.
DOMAIN 28 123 Ig-like V-type.
DOMAIN 148 231 Ig-like C2-type 1.
DOMAIN 238 333 Ig-like C2-type 2.
MOTIF 424 429 ITIM motif.
MOTIF 444 449 SLAM-like motif.
DISULFID 46 172 By similarity.
DISULFID 51 104 By similarity.
DISULFID 166 215 By similarity.
DISULFID 274 319 By similarity.
Amino Acid Sequence for SIGL6_HUMAN » Sialic acid-binding Ig-like lectin 6
MQGAQEASAS EMLPLLLPLL WAGALAQERR FQLEGPESLT VQEGLCVLVP CRLPTTLPAS YYGYGYWFLE GADVPVATND PDEEVQEETR GRFHLLWDPR RKNCSLSIRD ARRRDNAAYF FRLKSKWMKY GYTSSKLSVR VMALTHRPNI SIPGTLESGH PSNLTCSVPW VCEQGTPPIF SWMSAAPTSL GPRTTQSSVL TITPRPQDHS TNLTCQVTFP GAGVTMERTI QLNVSYAPQK VAISIFQGNS AAFKILQNTS SLPVLEGQAL RLLCDADGNP PAHLSWFQGF PALNATPISN TGVLELPQVG SAEEGDFTCR AQHPLGSLQI SLSLFVHWKP EGRAGGVLGA VWGASITTLV FLCVCFIFRV KTRRKKAAQP VQNTDDVNPV MVSGSRGHQH QFQTGIVSDH PAEAGPISED EQELHYAVLH FHKVQPQEPK VTDTEYSEIK IHK