SIGL5_HUMAN » Sialic acid-binding Ig-like lectin 5

SIGL5_HUMAN » Sialic acid-binding Ig-like lectin 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIGL5_HUMAN » Sialic acid-binding Ig-like lectin 5 » Siglec-5; CD33 antigen-like 2;Obesity-binding protein 2;OB-BP2; OB-binding protein 2;
Hydrophobic Thickness 40.0 ± 1.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -51.9 kcal/mol
ΔGfold -19.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 436-464 (436-466)
Pathways none
PDB 2zg1 (20-233), 2zg2 (20-233), 2zg3 (20-233)
OPM none
Complexes none
Interactions

TYOBP, Complex: SIGL5:TYOBP, PubMed

Domains

AA: 24-140, PDBID: 2ZG1, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for SIGL5_HUMAN » Sialic acid-binding Ig-like lectin 5
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

TISSUE SPECIFICITY: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for SIGL5_HUMAN » Sialic acid-binding Ig-like lectin 5
SIGNAL 1 16 Potential.
CHAIN 17 551 Sialic acid-binding Ig-like lectin 5.
DOMAIN 19 136 Ig-like V-type.
DOMAIN 146 229 Ig-like C2-type 1.
DOMAIN 236 330 Ig-like C2-type 2.
MOTIF 518 523 ITIM motif.
MOTIF 542 547 SLAM-like motif.
DISULFID 36 170
DISULFID 41 101
DISULFID 164 213
DISULFID 269 314 By similarity.
Amino Acid Sequence for SIGL5_HUMAN » Sialic acid-binding Ig-like lectin 5
MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW YSSPPLYVYW FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN CSLSIGDARM EDTGSYFFRV ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF LEPLESGRPT RLSCSLPGSC EAGPPLTFSW TGNALSPLDP ETTRSSELTL TPRPEDHGTN LTCQMKRQGA QVTTERTVQL NVSYAPQTIT IFRNGIALEI LQNTSYLPVL EGQALRLLCD APSNPPAHLS WFQGSPALNA TPISNTGILE LRRVRSAEEG GFTCRAQHPL GFLQIFLNLS VYSLPQLLGP SCSWEAEGLH CRCSFRARPA PSLCWRLEEK PLEGNSSQGS FKVNSSSAGP WANSSLILHG GLSSDLKVSC KAWNIYGSQS GSVLLLQGRS NLGTGVVPAA LGGAGVMALL CICLCLIFFL IVKARRKQAA GRPEKMDDED PIMGTITSGS RKKPWPDSPG DQASPPGDAP PLEEQKELHY ASLSFSEMKS REPKDQEAPS TTEYSEIKTS K