SIGIR_HUMAN » Single Ig IL-1-related receptor

SIGIR_HUMAN » Single Ig IL-1-related receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIGIR_HUMAN » Single Ig IL-1-related receptor » Single Ig IL-1R-related molecule;Single immunoglobulin domain-containing IL1R-related protein;Toll/interleukin-1 receptor 8;TIR8;
Hydrophobic Thickness 34.2 ± 1.7 Å
Tilt Angle 2 ± 2°
ΔGtransfer -25.4 kcal/mol
ΔGfold -26.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 119-141 (115-144)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:SIGIR, PubMed

IL1R1, Complex: SIGIR:TRAF6:IL1R1:MYD88:IRAK1, PubMed

RPN1, Complex: RPN1:SIGIR, PubMed

TLR4, Complex: SIGIR:TRAF6:MYD88:IRAK1:TLR4, PubMed

TLR5, Complex: TLR5:SIGIR, PubMed

TLR9, Complex: TLR9:SIGIR, PubMed

Domains

AA: 164-328, PDBID: 1T3G, Subunit B, Seq Identity:26%, TIR domain

UniProt annotation for SIGIR_HUMAN » Single Ig IL-1-related receptor
FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

SUBUNIT: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3.

TISSUE SPECIFICITY: Mainly expressed in epithelial tissues such as kidney, lung and gut.

INDUCTION: Down-regulated during inflammation by inhibition of an SP1-mediated pathway.

UniProt features for SIGIR_HUMAN » Single Ig IL-1-related receptor
CHAIN 1 410 Single Ig IL-1-related receptor.
DOMAIN 9 109 Ig-like C2-type.
DOMAIN 163 310 TIR.
DISULFID 32 98 By similarity.
Amino Acid Sequence for SIGIR_HUMAN » Single Ig IL-1-related receptor
MPGVCDRAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL KDGLPLGIGG HYSLHEYSWV KANLSEVLVS SVLGVNVTST EVYGAFTCSI QNISFSSFTL QRAGPTSHVA AVLASLLVLL ALLLAALLYV KCRLNVLLWY QDAYGEVEIN DGKLYDAYVS YSDCPEDRKF VNFILKPQLE RRRGYKLFLD DRDLLPRAEP SADLLVNLSR CRRLIVVLSD AFLSRAWCSH SFREGLCRLL ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW KEVQLALPRK VRYRPVEGDP QTQLQDDKDP MLILRGRVPE GRALDSEVDP DPEGDLGVRG PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM