SIG16_HUMAN » Sialic acid-binding Ig-like lectin 16

SIG16_HUMAN » Sialic acid-binding Ig-like lectin 16
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIG16_HUMAN » Sialic acid-binding Ig-like lectin 16 » Siglec-16; Siglec-P16;
Hydrophobic Thickness 34.8 ± 4.4 Å
Tilt Angle 37 ± 5°
ΔGtransfer -26.3 kcal/mol
ΔGfold -14.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 431-456 (431-467)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 25-141, PDBID: 1NKO, Subunit A, Seq Identity:43%, Immunoglobulin V-set domain

AA: 239-323, PDBID: 1RY7, Subunit B, Seq Identity:33%, Immunoglobulin I-set domain

AA: 344-412, PDBID: 3DMK, Subunit C, Seq Identity:33%, Immunoglobulin domain

UniProt annotation for SIG16_HUMAN » Sialic acid-binding Ig-like lectin 16
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells.

TISSUE SPECIFICITY: Expressed in bone marrow, fetal brain, fetal liver, lung and salivary gland. Detected in brain, macrophage, cancerous esophagus and lung at protein level.

UniProt features for SIG16_HUMAN » Sialic acid-binding Ig-like lectin 16
SIGNAL 1 16 Potential.
CHAIN 17 481 Sialic acid-binding Ig-like lectin 16.
DOMAIN 19 122 Ig-like V-type.
DOMAIN 147 232 Ig-like C2-type 1.
DOMAIN 238 322 Ig-like C2-type 2.
DOMAIN 327 424 Ig-like C2-type 3.
DISULFID 37 174 By similarity.
DISULFID 42 102 By similarity.
DISULFID 165 216 By similarity.
DISULFID 259 306 By similarity.
DISULFID 363 408 By similarity.
Amino Acid Sequence for SIG16_HUMAN » Sialic acid-binding Ig-like lectin 16
MLLLPLLLPV LGAGSLNKDP SYSLQVQRQV PVPEGLCVIV SCNLSYPRDG WDESTAAYGY WFKGRTSPKT GAPVATNNQS REVAMSTRDR FQLTGDPGKG SCSLVIRDAQ REDEAWYFFR VERGSRVRHS FLSNAFFLKV TALTQKPDVY IPETLEPGQP VTVICVFNWA FKKCPAPSFS WTGAALSPRR TRPSTSHFSV LSFTPSPQDH DTDLTCHVDF SRKGVSAQRT VRLRVASLEL QGNVIYLEVQ KGQFLRLLCA ADSQPPATLS WVLQDRVLSS SHPWGPRTLG LELPGVKAGD SGRYTCRAEN RLGSQQRALD LSVQYPPENL RVMVSQANRT VLENLRNGTS LRVLEGQSLR LVCVTHSSPP ARLSWTWGEQ TVGPSQPSDP GVLQLPRVQM EHEGEFTCHA RHPLGSQRVS LSFSVHCKSG PMTGVVLVAV GEVAMKILLL CLCLILLRVR SCRRKAARAA LGMEAADAVT D