SIG15_HUMAN » Sialic acid-binding Ig-like lectin 15

SIG15_HUMAN » Sialic acid-binding Ig-like lectin 15
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIG15_HUMAN » Sialic acid-binding Ig-like lectin 15 » Siglec-15; CD33 antigen-like 3;
Hydrophobic Thickness 34.6 ± 1.2 Å
Tilt Angle 11 ± 10°
ΔGtransfer -20.5 kcal/mol
ΔGfold -15.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 262-284 (258-289)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 47-165, PDBID: 2ZG1, Subunit A, Seq Identity:26%, Immunoglobulin V-set domain

UniProt annotation for SIG15_HUMAN » Sialic acid-binding Ig-like lectin 15
FUNCTION: Binds sialylated glycoproteins.

SUBUNIT: Interacts with TYROBP and HCST.

TISSUE SPECIFICITY: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

UniProt features for SIG15_HUMAN » Sialic acid-binding Ig-like lectin 15
SIGNAL 1 19 Potential.
CHAIN 20 328 Sialic acid-binding Ig-like lectin 15.
DOMAIN 40 158 Ig-like V-type.
DOMAIN 168 251 Ig-like C2-type.
DISULFID 64 142 By similarity.
DISULFID 95 104 Potential.
DISULFID 187 237 By similarity.
Amino Acid Sequence for SIG15_HUMAN » Sialic acid-binding Ig-like lectin 15
MEKSIWLLAC LAWVLPTGSF VRTKIDTTEN LLNTEVHSSP AQRWSMQVPP EVSAEAGDAA VLPCTFTHPH RHYDGPLTAI WRAGEPYAGP QVFRCAAARG SELCQTALSL HGRFRLLGNP RRNDLSLRVE RLALADDRRY FCRVEFAGDV HDRYESRHGV RLHVTAAPRI VNISVLPSPA HAFRALCTAE GEPPPALAWS GPALGNSLAA VRSPREGHGH LVTAELPALT HDGRYTCTAA NSLGRSEASV YLFRFHGASG ASTVALLLGA LGFKALLLLG VLAARAARRR PEHLDTPDTP PRSQAQESNY ENLSQMNPRS PPATMCSP