SIG14_HUMAN » Sialic acid-binding Ig-like lectin 14

SIG14_HUMAN » Sialic acid-binding Ig-like lectin 14
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIG14_HUMAN » Sialic acid-binding Ig-like lectin 14 » Siglec-14;
Hydrophobic Thickness 35.2 ± 1.0 Å
Tilt Angle 26 ± 0°
ΔGtransfer -22.4 kcal/mol
ΔGfold -9.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 355-380 (355-384)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions

TYOBP, Complex: TYOBP:SIG14, PubMed

Domains

AA: 24-140, PDBID: 2ZG1, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 254-336, PDBID: 3NVQ, Subunit A, Seq Identity:30%, Immunoglobulin domain

UniProt annotation for SIG14_HUMAN » Sialic acid-binding Ig-like lectin 14
FUNCTION: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.

SUBUNIT: Interacts with TYROBP.

TISSUE SPECIFICITY: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also detected in lung and testis.

UniProt features for SIG14_HUMAN » Sialic acid-binding Ig-like lectin 14
SIGNAL 1 16 Potential.
CHAIN 17 396 Sialic acid-binding Ig-like lectin 14.
DOMAIN 19 136 Ig-like V-type.
DOMAIN 146 229 Ig-like C2-type 1.
DOMAIN 236 331 Ig-like C2-type 2.
DISULFID 164 213 By similarity.
DISULFID 274 319 By similarity.
Amino Acid Sequence for SIG14_HUMAN » Sialic acid-binding Ig-like lectin 14
MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW YSSPPLYVYW FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN CSLSIGDARM EDTGSYFFRV ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF LEPLESGRPT RLSCSLPGSC EAGPPLTFSW TGNALSPLDP ETTRSSELTL TPRPEDHGTN LTCQVKRQGA QVTTERTVQL NVSYAPQNLA ISIFFRNGTG TALRILSNGM SVPIQEGQSL FLACTVDSNP PASLSWFREG KALNPSQTSM SGTLELPNIG AREGGEFTCR VQHPLGSQHL SFILSVQRSS SSCICVTEKQ QGSWPLVLTL IRGALMGAGF LLTYGLTWIY YTRCGGPQQS RAERPG