SIG12_HUMAN » Sialic acid-binding Ig-like lectin 12

SIG12_HUMAN » Sialic acid-binding Ig-like lectin 12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIG12_HUMAN » Sialic acid-binding Ig-like lectin 12 » Siglec-12; Sialic acid-binding Ig-like lectin-like 1;Siglec-L1;
Hydrophobic Thickness 37.6 ± 2.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.9 kcal/mol
ΔGfold -15.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 482-504 (476-510)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 27-142, PDBID: 1NKO, Subunit A, Seq Identity:56%, Immunoglobulin V-set domain

AA: 154-269, PDBID: 1NKO, Subunit A, Seq Identity:52%, Immunoglobulin V-set domain

AA: 380-450, PDBID: 3P3Y, Subunit A, Seq Identity:34%, Immunoglobulin domain

UniProt annotation for SIG12_HUMAN » Sialic acid-binding Ig-like lectin 12
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

TISSUE SPECIFICITY: Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for SIG12_HUMAN » Sialic acid-binding Ig-like lectin 12
SIGNAL 1 18 Potential.
CHAIN 19 595 Sialic acid-binding Ig-like lectin 12.
DOMAIN 19 142 Ig-like V-type 1.
DOMAIN 143 269 Ig-like V-type 2.
DOMAIN 275 358 Ig-like C2-type 1.
DOMAIN 365 462 Ig-like C2-type 2.
MOTIF 563 568 ITIM motif.
MOTIF 586 591 SLAM-like motif.
DISULFID 44 104 By similarity.
DISULFID 166 299 By similarity.
DISULFID 171 231 By similarity.
DISULFID 293 342 By similarity.
DISULFID 401 446 By similarity.
Amino Acid Sequence for SIG12_HUMAN » Sialic acid-binding Ig-like lectin 12
MLLLLLLLPP LLCGRVGAKE QKDYLLTMQK SVTVQEGLCV SVLCSFSYPQ NGWTASDPVH GYWFRAGDHV SRNIPVATNN PARAVQEETR DRFHLLGDPQ NKDCTLSIRD TRESDAGTYV FCVERGNMKW NYKYDQLSVN VTASQDLLSR YRLEVPESVT VQEGLCVSVP CSVLYPHYNW TASSPVYGSW FKEGADIPWD IPVATNTPSG KVQEDTHGRF LLLGDPQTNN CSLSIRDARK GDSGKYYFQV ERGSRKWNYI YDKLSVHVTA LTHMPTFSIP GTLESGHPRN LTCSVPWACE QGTPPTITWM GASVSSLDPT ITRSSMLSLI PQPQDHGTSL TCQVTLPGAG VTMTRAVRLN ISYPPQNLTM TVFQGDGTAS TTLRNGSALS VLEGQSLHLV CAVDSNPPAR LSWTWGSLTL SPSQSSNLGV LELPRVHVKD EGEFTCRAQN PLGSQHISLS LSLQNEYTGK MRPISGVTLG AFGGAGATAL VFLYFCIIFV VVRSCRKKSA RPAVGVGDTG MEDANAVRGS ASQGPLIESP ADDSPPHHAP PALATPSPEE GEIQYASLSF HKARPQYPQE QEAIGYEYSE INIPK