SIG11_HUMAN » Sialic acid-binding Ig-like lectin 11

SIG11_HUMAN » Sialic acid-binding Ig-like lectin 11
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIG11_HUMAN » Sialic acid-binding Ig-like lectin 11 » Sialic acid-binding lectin 11; Siglec-11;
Hydrophobic Thickness 27.6 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -24.9 kcal/mol
ΔGfold -13.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 549-574 (549-586)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 37-153, PDBID: 1NKO, Subunit A, Seq Identity:43%, Immunoglobulin V-set domain

AA: 267-351, PDBID: 1RY7, Subunit B, Seq Identity:34%, Immunoglobulin I-set domain

AA: 373-440, PDBID: 3DMK, Subunit C, Seq Identity:32%, Immunoglobulin domain

UniProt annotation for SIG11_HUMAN » Sialic acid-binding Ig-like lectin 11
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

SUBUNIT: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.

TISSUE SPECIFICITY: Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for SIG11_HUMAN » Sialic acid-binding Ig-like lectin 11
SIGNAL 1 27 Potential.
CHAIN 28 698 Sialic acid-binding Ig-like lectin 11.
DOMAIN 31 134 Ig-like V-type.
DOMAIN 159 244 Ig-like C2-type 1.
DOMAIN 251 350 Ig-like C2-type 2.
DOMAIN 355 452 Ig-like C2-type 3.
MOTIF 642 647 ITIM motif.
DISULFID 49 186 By similarity.
DISULFID 54 114 By similarity.
DISULFID 177 228 By similarity.
DISULFID 287 334 By similarity.
DISULFID 391 436 By similarity.
Amino Acid Sequence for SIG11_HUMAN » Sialic acid-binding Ig-like lectin 11
MLLLPLLLPV LGAGSLNKDP SYSLQVQRQV PVPEGLCVIV SCNLSYPRDG WDESTAAYGY WFKGRTSPKT GAPVATNNQS REVEMSTRDR FQLTGDPGKG SCSLVIRDAQ REDEAWYFFR VERGSRVRHS FLSNAFFLKV TALTKKPDVY IPETLEPGQP VTVICVFNWA FKKCPAPSFS WTGAALSPRR TRPSTSHFSV LSFTPSPQDH DTDLTCHVDF SRKGVSAQRT VRLRVAYAPK DLIISISHDN TSALELQGNV IYLEVQKGQF LRLLCAADSQ PPATLSWVLQ DRVLSSSHPW GPRTLGLELR GVRAGDSGRY TCRAENRLGS QQQALDLSVQ YPPENLRVMV SQANRTVLEN LGNGTSLPVL EGQSLRLVCV THSSPPARLS WTRWGQTVGP SQPSDPGVLE LPPIQMEHEG EFTCHAQHPL GSQHVSLSLS VHYPPQLLGP SCSWEAEGLH CSCSSQASPA PSLRWWLGEE LLEGNSSQGS FEVTPSSAGP WANSSLSLHG GLSSGLRLRC KAWNVHGAQS GSVFQLLPGK LEHGGGLGLG AALGAGVAAL LAFCSCLVVF RVKICRKEAR KRAAAEQDVP STLGPISQGH QHECSAGSSQ DHPPPGAATY TPGKGEEQEL HYASLSFQGL RLWEPADQEA PSTTEYSEIK IHTGQPLRGP GFGLQLEREM SGMVPK