SIG10_HUMAN » Sialic acid-binding Ig-like lectin 10

SIG10_HUMAN » Sialic acid-binding Ig-like lectin 10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SIG10_HUMAN » Sialic acid-binding Ig-like lectin 10 » Siglec-10; Siglec-like protein 2;
Hydrophobic Thickness 31.2 ± 3.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.3 kcal/mol
ΔGfold -19.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 548-574 (546-574)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 24-140, PDBID: 1NKO, Subunit A, Seq Identity:47%, Immunoglobulin V-set domain

AA: 251-340, PDBID: 2ENS, Subunit A, Seq Identity:23%, Immunoglobulin domain

AA: 362-429, PDBID: 3DMK, Subunit C, Seq Identity:36%, Immunoglobulin domain

UniProt annotation for SIG10_HUMAN » Sialic acid-binding Ig-like lectin 10
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

SUBUNIT: Interacts with PTPN6/SHP-1 upon phosphorylation.

TISSUE SPECIFICITY: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for SIG10_HUMAN » Sialic acid-binding Ig-like lectin 10
SIGNAL 1 16 Potential.
CHAIN 17 697 Sialic acid-binding Ig-like lectin 10.
DOMAIN 18 121 Ig-like V-type.
DOMAIN 146 231 Ig-like C2-type 1.
DOMAIN 251 339 Ig-like C2-type 2.
DOMAIN 344 441 Ig-like C2-type 3.
MOTIF 595 600 ITIM motif 1.
MOTIF 665 670 ITIM motif 2.
DISULFID 36 173 By similarity.
DISULFID 41 101 By similarity.
DISULFID 164 215 By similarity.
DISULFID 276 323 By similarity.
DISULFID 380 425 By similarity.
Amino Acid Sequence for SIG10_HUMAN » Sialic acid-binding Ig-like lectin 10
MLLPLLLSSL LGGSQAMDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW TGSTPAYGYW FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN CSLVIRDAQM QDESQYFFRV ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI PETLEPGQPV TVICVFNWAF EECPPPSFSW TGAALSSQGT KPTTSHFSVL SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD LVISISRDNT PALEPQPQGN VPYLEAQKGQ FLRLLCAADS QPPATLSWVL QNRVLSSSHP WGPRPLGLEL PGVKAGDSGR YTCRAENRLG SQQRALDLSV QYPPENLRVM VSQANRTVLE NLGNGTSLPV LEGQSLCLVC VTHSSPPARL SWTQRGQVLS PSQPSDPGVL ELPRVQVEHE GEFTCHARHP LGSQHVSLSL SVHYSPKLLG PSCSWEAEGL HCSCSSQASP APSLRWWLGE ELLEGNSSQD SFEVTPSSAG PWANSSLSLH GGLSSGLRLR CEAWNVHGAQ SGSILQLPDK KGLISTAFSN GAFLGIGITA LLFLCLALII MKILPKRRTQ TETPRPRFSR HSTILDYINV VPTAGPLAQK RNQKATPNSP RTPLPPGAPS PESKKNQKKQ YQLPSFPEPK SSTQAPESQE SQEELHYATL NFPGVRPRPE ARMPKGTQAD YAEVKFQ