SHSA5_HUMAN » Protein shisa-5

SHSA5_HUMAN » Protein shisa-5
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SHSA5_HUMAN » Protein shisa-5 » Putative NF-kappa-B-activating protein 120;Scotin;
Hydrophobic Thickness 30.8 ± 5.0 Å
Tilt Angle 29 ± 0°
ΔGtransfer -24.6 kcal/mol
ΔGfold -19.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 109-131 (105-141)
Pathways

p53 signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

ALG2, Complex: ALG2:SHSA5, PubMed

Domains

AA: 28-199, Wnt and FGF inhibitory regulator

UniProt annotation for SHSA5_HUMAN » Protein shisa-5
FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.

SUBUNIT: Interacts with PDCD6; PDCD6 can stabilze SHISA5.

INDUCTION: Induced in a p53/TP53-dependent manner in response to cellular stress.

DOMAIN: The proline-rich region is required for endoplasmic reticulum localization.

UniProt features for SHSA5_HUMAN » Protein shisa-5
SIGNAL 1 28 Potential.
CHAIN 29 240 Protein shisa-5.
Amino Acid Sequence for SHSA5_HUMAN » Protein shisa-5
MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG TCDDQYCCSD VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN DPMSGFGATL AVGLTIFVLS VVTIIICFTC SCCCLYKTCR RPRPVVTTTT STTVVHAPYP QPPSVPPSYP GPSYQGYHTM PPQPGMPAAP YPMQYPPPYP AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL