SHSA2_HUMAN » Protein shisa-2 homolog

SHSA2_HUMAN » Protein shisa-2 homolog
Magnify SHSA2_HUMAN » Protein shisa-2 homologEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SHSA2_HUMAN » Protein shisa-2 homolog » Transmembrane protein 46;
Hydrophobic Thickness 33.0 ± 2.0 Å
Tilt Angle 12 ± 0°
ΔGtransfer -22.4 kcal/mol
ΔGfold -15.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 115-136 (115-138)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 35-224, Wnt and FGF inhibitory regulator

UniProt annotation for SHSA2_HUMAN » Protein shisa-2 homolog
FUNCTION: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.
UniProt features for SHSA2_HUMAN » Protein shisa-2 homolog
SIGNAL 1 33
CHAIN 34 295 Protein shisa-2 homolog.
Amino Acid Sequence for SHSA2_HUMAN » Protein shisa-2 homolog
MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI GFQCPERFDG GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG RADKDGPDGS AVPIYVPFLI VGSVFVAFII LGSLVAACCC RCLRPKQDPQ QSRAPGGNRL METIPMIPSA STSRGSSSRQ SSTAASSSSS ANSGARAPPT RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG QYLHPPYVGY TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV