SHPS1_HUMAN » Tyrosine-protein phosphatase non-receptor type substrate 1

SHPS1_HUMAN » Tyrosine-protein phosphatase non-receptor type substrate 1
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Topology in Plasma membrane
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SHPS1_HUMAN » Tyrosine-protein phosphatase non-receptor type substrate 1 » SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs;Bit; CD172 antigen-like family member A;Inhibitory receptor SHPS-1;Macrophage fusion receptor;MyD-1 antigen;Signal-regulatory protein alpha-1;Sirp-alpha-1; Signal-regula
Hydrophobic Thickness 37.2 ± 2.0 Å
Tilt Angle 3 ± 2°
ΔGtransfer -36.1 kcal/mol
ΔGfold -21.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 370-393 (366-400)
Pathways

Cell-Cell communication (Reactome)

Hemostasis (Reactome)

Osteoclast differentiation (KEGG)

PDB 2wng (31-350), 2jjs (A/B=31-149), 2jjt (A/B=31-149), 2uv3 (A/B=31-149), 4cmm (A=31-149)
OPM none
Complexes

SHPS1:SHPS1_HUMAN

Interactions

IL1AP, Complex: IL1AP:SHPS1, PubMed

ITB1, Complex: ITB1:SHPS1, PubMed

PRLR, Complex: PRLR:SHPS1, PubMed

SHPS1, Complex: Homodimer of tyrosine-protein phosphatase non-receptor type substrate 1, PDBID: 2UV3

Domains

AA: 38-145, PDBID: 2JJS, Subunit B, Seq Identity:100%, Immunoglobulin V-set domain

AA: 148-235, PDBID: 2WNG, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 253-338, PDBID: 2WNG, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for SHPS1_HUMAN » Tyrosine-protein phosphatase non-receptor type substrate 1
FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SUBUNIT: Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

UniProt features for SHPS1_HUMAN » Tyrosine-protein phosphatase non-receptor type substrate 1
SIGNAL 1 30 Potential.
CHAIN 31 504 Tyrosine-protein phosphatase non-receptor type substrate 1.
DOMAIN 32 137 Ig-like V-type.
DOMAIN 148 247 Ig-like C1-type 1.
DOMAIN 254 348 Ig-like C1-type 2.
MOTIF 429 432 SH2-binding (Potential).
MOTIF 439 444 SH3-binding (Potential).
MOTIF 453 456 SH2-binding (Potential).
MOTIF 470 473 SH2-binding (Potential).
MOTIF 496 499 SH2-binding (Potential).
DISULFID 55 121
DISULFID 170 228 Potential.
DISULFID 273 331 Potential.
Amino Acid Sequence for SHPS1_HUMAN » Tyrosine-protein phosphatase non-receptor type substrate 1
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVSVAAGES AILHCTVTSL IPVGPIQWFR GAGPARELIY NQKEGHFPRV TTVSESTKRE NMDFSISISN ITPADAGTYY CVKFRKGSPD TEFKSGAGTE LSVRAKPSAP VVSGPAARAT PQHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDFQTNVDPV GESVSYSIHS TAKVVLTRED VHSQVICEVA HVTLQGDPLR GTANLSETIR VPPTLEVTQQ PVRAENQVNV TCQVRKFYPQ RLQLTWLENG NVSRTETAST VTENKDGTYN WMSWLLVNVS AHRDDVKLTC QVEHDGQPAV SKSHDLKVSA HPKEQGSNTA AENTGSNERN IYIVVGVVCT LLVALLMAAL YLVRIRQKKA QGSTSSTRLH EPEKNAREIT QDTNDITYAD LNLPKGKKPA PQAAEPNNHT EYASIQTSPQ PASEDTLTYA DLDMVHLNRT PKQPAPKPEP SFSEYASVQV PRK