SEZ6_HUMAN » Seizure protein 6 homolog

SEZ6_HUMAN » Seizure protein 6 homolog
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEZ6_HUMAN » Seizure protein 6 homolog » SEZ-6; hSEZ-6;
Hydrophobic Thickness 34.8 ± 1.6 Å
Tilt Angle 28 ± 1°
ΔGtransfer -28.7 kcal/mol
ΔGfold -20.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 923-949 (923-951)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 357-412, PDBID: 1C1Z, Subunit A, Seq Identity:33%, Sushi repeat (SCR repeat)

AA: 416-524, PDBID: 4GZ9, Subunit A, Seq Identity:31%, CUB domain

AA: 532-589, PDBID: 1G40, Subunit B, Seq Identity:32%, Sushi repeat (SCR repeat)

AA: 593-701, PDBID: 2QQK, Subunit A, Seq Identity:31%, CUB domain

AA: 710-765, PDBID: 2YRA, Subunit A, Seq Identity:63%, Sushi repeat (SCR repeat)

AA: 771-830, PDBID: 1G40, Subunit B, Seq Identity:32%, Sushi repeat (SCR repeat)

AA: 838-895, PDBID: 1H03, Subunit P, Seq Identity:38%, Sushi repeat (SCR repeat)

UniProt annotation for SEZ6_HUMAN » Seizure protein 6 homolog
FUNCTION: May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity).
UniProt features for SEZ6_HUMAN » Seizure protein 6 homolog
SIGNAL 1 19 Potential.
CHAIN 20 994 Seizure protein 6 homolog.
DOMAIN 355 414 Sushi 1.
DOMAIN 416 527 CUB 1.
DOMAIN 530 591 Sushi 2.
DOMAIN 593 704 CUB 2.
DOMAIN 708 767 Sushi 3.
DOMAIN 769 832 Sushi 4.
DOMAIN 836 897 Sushi 5.
REGION 38 47 O-glycosylated at two sites.
REGION 59 63 O-glycosylated at two sites.
DISULFID 357 397 By similarity.
DISULFID 383 412 By similarity.
DISULFID 416 443 By similarity.
DISULFID 532 574 By similarity.
DISULFID 559 589 By similarity.
DISULFID 593 619 By similarity.
DISULFID 710 752 By similarity.
DISULFID 738 765 By similarity.
DISULFID 771 813 By similarity.
DISULFID 799 830 By similarity.
DISULFID 838 880 By similarity.
DISULFID 866 895 By similarity.
Amino Acid Sequence for SEZ6_HUMAN » Seizure protein 6 homolog
MRPVALLLLP SLLALLAHGL SLEAPTVGKG QAPGIEETDG ELTAAPTPEQ PERGVHFVTT APTLKLLNHH PLLEEFLQEG LEKGDEELRP ALPFQPDPPA PFTPSPLPRL ANQDSRPVFT SPTPAMAAVP TQPQSKEGPW SPESESPMLR ITAPLPPGPS MAVPTLGPGE IASTTPPSRA WTPTQEGPGD MGRPWVAEVV SQGAGIGIQG TITSSTASGD DEETTTTTTI ITTTITTVQT PGPCSWNFSG PEGSLDSPTD LSSPTDVGLD CFFYISVYPG YGVEIKVQNI SLREGETVTV EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY QAYLLSCHFP RRPAYGDVTV TSLHPGGSAR FHCATGYQLK GARHLTCLNA TQPFWDSKEP VCIAACGGVI RNATTGRIVS PGFPGNYSNN LTCHWLLEAP EGQRLHLHFE KVSLAEDDDR LIIRNGDNVE APPVYDSYEV EYLPIEGLLS SGKHFFVELS TDSSGAAAGM ALRYEAFQQG HCYEPFVKYG NFSSSTPTYP VGTTVEFSCD PGYTLEQGSI IIECVDPHDP QWNETEPACR AVCSGEITDS AGVVLSPNWP EPYGRGQDCI WGVHVEEDKR IMLDIRVLRI GPGDVLTFYD GDDLTARVLG QYSGPRSHFK LFTSMADVTI QFQSDPGTSV LGYQQGFVIH FFEVPRNDTC PELPEIPNGW KSPSQPELVH GTVVTYQCYP GYQVVGSSVL MCQWDLTWSE DLPSCQRVTS CHDPGDVEHS RRLISSPKFP VGATVQYICD QGFVLMGSSI LTCHDRQAGS PKWSDRAPKC LLEQLKPCHG LSAPENGARS PEKQLHPAGA TIHFSCAPGY VLKGQASIKC VPGHPSHWSD PPPICRAASL DGFYNSRSLD VAKAPAASST LDAAHIAAAI FLPLVAMVLL VGGVYFYFSR LQGKSSLQLP RPRPRPYNRI TIESAFDNPT YETGSLSFAG DERI