SERP1_HUMAN » Stress-associated endoplasmic reticulum protein 1

SERP1_HUMAN » Stress-associated endoplasmic reticulum protein 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SERP1_HUMAN » Stress-associated endoplasmic reticulum protein 1 » Ribosome-attached membrane protein 4;
Hydrophobic Thickness 29.4 ± 4.0 Å
Tilt Angle 25 ± 3°
ΔGtransfer -21.6 kcal/mol
ΔGfold -16.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 37-59 (32-64)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:SERP1, PubMed

CALX, Complex: SERP1:CALX, PubMed

SC61B, Complex: SC61B:SERP1, PubMed

Domains

AA: 2-62, Ribosome associated membrane protein RAMP4

UniProt annotation for SERP1_HUMAN » Stress-associated endoplasmic reticulum protein 1
FUNCTION: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).

SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).

UniProt features for SERP1_HUMAN » Stress-associated endoplasmic reticulum protein 1
CHAIN 1 66 Stress-associated endoplasmic reticulum protein 1.
Amino Acid Sequence for SERP1_HUMAN » Stress-associated endoplasmic reticulum protein 1
MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APEEKASVGP WLLALFIFVV CGSAIFQIIQ SIRMGM