SEM7A_HUMAN » Semaphorin-7A

SEM7A_HUMAN » Semaphorin-7A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM7A_HUMAN » Semaphorin-7A » CDw108;JMH blood group antigen;John-Milton-Hargen human blood group Ag;Semaphorin-K1;Sema K1; Semaphorin-L;Sema L;
Hydrophobic Thickness 34.4 ± 5.4 Å
Tilt Angle 36 ± 3°
ΔGtransfer -13.8 kcal/mol
ΔGfold -8.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 636-665 (636-665)
Pathways none
PDB 3nvq (A/E=45-634)
OPM none
Complexes

PLXC1:SEM7A_HUMAN

Interactions

PLXC1, Complex: PLXC1:SEM7A, PDBID: 3NVQ

Domains

AA: 77-471, PDBID: 3NVQ, Subunit A, Seq Identity:100%, Sema domain

AA: 492-550, PDBID: 3NVQ, Subunit A, Seq Identity:100%, Plexin repeat

AA: 545-628, PDBID: 3NVQ, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for SEM7A_HUMAN » Semaphorin-7A
FUNCTION: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

SUBUNIT: Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1.

TISSUE SPECIFICITY: Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.

INDUCTION: Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes.

UniProt features for SEM7A_HUMAN » Semaphorin-7A
SIGNAL 1 44
CHAIN 45 648 Semaphorin-7A.
PROPEP 649 666 Removed in mature form.
DOMAIN 53 490 Sema.
DOMAIN 544 629 Ig-like C2-type.
REGION 267 269 Interaction with integrins.
MOTIF 267 269 Cell attachment site.
DISULFID 120 126
DISULFID 143 152
DISULFID 266 366
DISULFID 291 335
DISULFID 493 511
DISULFID 500 541
DISULFID 503 518
DISULFID 566 613
DISULFID 587 596
Amino Acid Sequence for SEM7A_HUMAN » Semaphorin-7A
MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS GPRIFAVWKG HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF PEGKNASVRT VNIGSTKGSC LDKRDCENYI TLLERRSEGL LACGTNARHP SCWNLVNGTV VPLGEMRGYA PFSPDENSLV LFEGDEVYST IRKQEYNGKI PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI YYFFREDNPD KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS LKGYHSSLPN PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP LFHSKYHYQK VAVHRMQASH GETFHVLYLT TDRGTIHKVV EPGEQEHSFA FNIMEIQPFR RAAAIQTMSL DAERRKLYVS SQWEVSQVPL DLCEVYGGGC HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE CPNPKPDKAP LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS LWLGVLPTLT LGLLVH