SEM6D_HUMAN » Semaphorin-6D

SEM6D_HUMAN » Semaphorin-6D
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM6D_HUMAN » Semaphorin-6D »
Hydrophobic Thickness 34.4 ± 4.8 Å
Tilt Angle 31 ± 0°
ΔGtransfer -25.4 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 661-686 (654-687)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

PLXA1, Complex: PLXA1:SEM6D, PubMed

Domains

AA: 61-481, PDBID: 3AFC, Subunit B, Seq Identity:63%, Sema domain

AA: 514-569, PDBID: 3AFC, Subunit B, Seq Identity:32%, Plexin repeat

UniProt annotation for SEM6D_HUMAN » Semaphorin-6D
FUNCTION: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
UniProt features for SEM6D_HUMAN » Semaphorin-6D
SIGNAL 1 20 Potential.
CHAIN 21 1073 Semaphorin-6D.
DOMAIN 27 512 Sema.
DOMAIN 514 569 PSI.
DISULFID 108 118 By similarity.
DISULFID 136 145 By similarity.
DISULFID 259 370 By similarity.
DISULFID 284 329 By similarity.
DISULFID 477 506 By similarity.
DISULFID 515 533 By similarity.
DISULFID 521 568 By similarity.
DISULFID 525 541 By similarity.
Amino Acid Sequence for SEM6D_HUMAN » Semaphorin-6D
MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE NEEDKKVISL QLDKDHHALY VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS CGRVTPGMLA EGYEQDTEFG NTAHLGDCHE ILPTSTTPDY KIFGGPTSDM EVSSSSVTTM ASIPEITPKV IDTWRPKLTS SRKFVVQDDP NTSDFTDPLS GIPKGVRWEV QSGESNQMVH MNVLITCVFA AFVLGAFIAG VAVYCYRDMF VRKNRKIHKD AESAQSCTDS SGSFAKLNGL FDSPVKEYQQ NIDSPKLYSN LLTSRKELPP NGDTKSMVMD HRGQPPELAA LPTPESTPVL HQKTLQAMKS HSEKAHGHGA SRKETPQFFP SSPPPHSPLS HGHIPSAIVL PNATHDYNTS FSNSNAHKAE KKLQNIDHPL TKSSSKRDHR RSVDSRNTLN DLLKHLNDPN SNPKAIMGDI QMAHQNLMLD PMGSMSEVPP KVPNREASLY SPPSTLPRNS PTKRVDVPTT PGVPMTSLER QRGYHKNSSQ RHSISAMPKN LNSPNGVLLS RQPSMNRGGY MPTPTGAKVD YIQGTPVSVH LQPSLSRQSS YTSNGTLPRT GLKRTPSLKP DVPPKPSFVP QTPSVRPLNK YTY