SEM6C_HUMAN » Semaphorin-6C

SEM6C_HUMAN » Semaphorin-6C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM6C_HUMAN » Semaphorin-6C » Semaphorin-Y;Sema Y;
Hydrophobic Thickness 33.2 ± 2.3 Å
Tilt Angle 29 ± 0°
ΔGtransfer -15.7 kcal/mol
ΔGfold -14.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 602-624 (602-635)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 68-479, PDBID: 3AFC, Subunit B, Seq Identity:50%, Sema domain

UniProt annotation for SEM6C_HUMAN » Semaphorin-6C
FUNCTION: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

TISSUE SPECIFICITY: In adult tissues, expressed only in skeletal muscle.

UniProt features for SEM6C_HUMAN » Semaphorin-6C
SIGNAL 1 24 Potential.
CHAIN 25 930 Semaphorin-6C.
DOMAIN 30 516 Sema.
DISULFID 111 121 By similarity.
DISULFID 139 148 By similarity.
DISULFID 262 373 By similarity.
DISULFID 287 332 By similarity.
DISULFID 479 510 By similarity.
DISULFID 519 537 By similarity.
DISULFID 525 570 By similarity.
DISULFID 529 545 By similarity.
Amino Acid Sequence for SEM6C_HUMAN » Semaphorin-6C
MPRAPHFMPL LLLLLLLSLP HTQAAFPQDP LPLLISDLQG TSPLSWFRGL EDDAVAAELG LDFQRFLTLN RTLLVAARDH VFSFDLQAEE EGEGLVPNKY LTWRSQDVEN CAVRGKLTDE CYNYIRVLVP WDSQTLLACG TNSFSPVCRS YGITSLQQEG EELSGQARCP FDATQSNVAI FAEGSLYSAT AADFQASDAV VYRSLGPQPP LRSAKYDSKW LREPHFVQAL EHGDHVYFFF REVSVEDARL GRVQFSRVAR VCKRDMGGSP RALDRHWTSF LKLRLNCSVP GDSTFYFDVL QALTGPVNLH GRSALFGVFT TQTNSIPGSA VCAFYLDEIE RGFEGKFKEQ RSLDGAWTPV SEDRVPSPRP GSCAGVGGAA LFSSSRDLPD DVLTFIKAHP LLDPAVPPVT HQPLLTLTSR ALLTQVAVDG MAGPHSNITV MFLGSNDGTV LKVLPPGGRS GGPEPILLEE IDAYSPARCS GKRTAQTARR IIGLELDTEG HRLFVAFSGC IVYLPLSRCA RHGACQRSCL ASQDPYCGWH SSRGCVDIRG SGGTDVDQAG NQESMEHGDC QDGATGSQSG PGDSAYGVRR DLPPASASRS VPIPLLLASV AAAFALGASV SGLLVSCACR RAHRRRGKDI ETPGLPRPLS LRSLARLHGG GPEPPPPSKD GDAVQTPQLY TTFLPPPEGV PPPELACLPT PESTPELPVK HLRAAGDPWE WNQNRNNAKE GPGRSRGGHA AGGPAPRVLV RPPPPGCPGQ AVEVTTLEEL LRYLHGPQPP RKGAEPPAPL TSRALPPEPA PALLGGPSPR PHECASPLRL DVPPEGRCAS APARPALSAP APRLGVGGGR RLPFSGHRAP PALLTRVPSG GPSRYSGGPG KHLLYLGRPE GYRGRALKRV DVEKPQLSLK PPLVGPSSRQ AVPNGGRFNF