SEM6B_HUMAN » Semaphorin-6B

SEM6B_HUMAN » Semaphorin-6B
Magnify SEM6B_HUMAN » Semaphorin-6BEnlarged view of image
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM6B_HUMAN » Semaphorin-6B » Semaphorin-Z;Sema Z;
Hydrophobic Thickness 34.0 ± 1.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -40.1 kcal/mol
ΔGfold -13.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 599-624 (596-633)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 70-486, PDBID: 3AFC, Subunit B, Seq Identity:62%, Sema domain

AA: 525-578, PDBID: 3AFC, Subunit B, Seq Identity:48%, Plexin repeat

UniProt annotation for SEM6B_HUMAN » Semaphorin-6B
FUNCTION: May play a role in both peripheral and central nervous system development.
UniProt features for SEM6B_HUMAN » Semaphorin-6B
SIGNAL 1 25
CHAIN 26 888 Semaphorin-6B.
DOMAIN 31 523 Sema.
DISULFID 116 126 By similarity.
DISULFID 144 153 By similarity.
DISULFID 267 378 By similarity.
DISULFID 292 337 By similarity.
DISULFID 486 517 By similarity.
DISULFID 526 544 By similarity.
DISULFID 532 578 By similarity.
DISULFID 536 552 By similarity.
Amino Acid Sequence for SEM6B_HUMAN » Semaphorin-6B
MQTPRASPPR PALLLLLLLL GGAHGLFPEE PPPLSVAPRD YLNHYPVFVG SGPGRLTPAE GADDLNIQRV LRVNRTLFIG DRDNLYRVEL EPPTSTELRY QRKLTWRSNP SDINVCRMKG KQEGECRNFV KVLLLRDEST LFVCGSNAFN PVCANYSIDT LQPVGDNISG MARCPYDPKH ANVALFSDGM LFTATVTDFL AIDAVIYRSL GDRPTLRTVK HDSKWFKEPY FVHAVEWGSH VYFFFREIAM EFNYLEKVVV SRVARVCKND VGGSPRVLEK QWTSFLKARL NCSVPGDSHF YFNVLQAVTG VVSLGGRPVV LAVFSTPSNS IPGSAVCAFD LTQVAAVFEG RFREQKSPES IWTPVPEDQV PRPRPGCCAA PGMQYNASSA LPDDILNFVK THPLMDEAVP SLGHAPWILR TLMRHQLTRV AVDVGAGPWG NQTVVFLGSE AGTVLKFLVR PNASTSGTSG LSVFLEEFET YRPDRCGRPG GGETGQRLLS LELDAASGGL LAAFPRCVVR VPVARCQQYS GCMKNCIGSQ DPYCGWAPDG SCIFLSPGTR AAFEQDVSGA STSGLGDCTG LLRASLSEDR AGLVSVNLLV TSSVAAFVVG AVVSGFSVGW FVGLRERREL ARRKDKEAIL AHGAGEAVLS VSRLGERRAQ GPGGRGGGGG GGAGVPPEAL LAPLMQNGWA KATLLQGGPH DLDSGLLPTP EQTPLPQKRL PTPHPHPHAL GPRAWDHGHP LLPASASSSL LLLAPARAPE QPPAPGEPTP DGRLYAARPG RASHGDFPLT PHASPDRRRV VSAPTGPLDP ASAADGLPRP WSPPPTGSLR RPLGPHAPPA ATLRRTHTFN SGEARPGDRH RGCHARPGTD LAHLLPYGGA DRTAPPVP