SEM6A_HUMAN » Semaphorin-6A

SEM6A_HUMAN » Semaphorin-6A
Magnify SEM6A_HUMAN » Semaphorin-6AEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM6A_HUMAN » Semaphorin-6A » Semaphorin VIA;Sema VIA; Semaphorin-6A-1;SEMA6A-1;
Hydrophobic Thickness 36.0 ± 2.2 Å
Tilt Angle 1 ± 2°
ΔGtransfer -49.1 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 642-671 (642-678)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes

SEM6A:PLXA2_MOUSE

SEM6A:SEM6A_MOUSE

Interactions

PLXA2, Complex: SEM6A:PLXA2, PDBID: 3AL8

SEM6A, Complex: Homodimer of semaphorin-6A, PDBID: 3OKW

Domains

AA: 61-479, PDBID: 3AFC, Subunit B, Seq Identity:95%, Sema domain

AA: 514-569, PDBID: 3AFC, Subunit B, Seq Identity:59%, Plexin repeat

UniProt annotation for SEM6A_HUMAN » Semaphorin-6A
FUNCTION: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).

SUBUNIT: Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer (By similarity). Interacts with EVL.

UniProt features for SEM6A_HUMAN » Semaphorin-6A
SIGNAL 1 18 Potential.
CHAIN 19 1030 Semaphorin-6A.
DOMAIN 24 512 Sema.
DISULFID 107 117 By similarity.
DISULFID 135 144 By similarity.
DISULFID 258 369 By similarity.
DISULFID 283 328 By similarity.
DISULFID 477 506 By similarity.
DISULFID 515 533 By similarity.
DISULFID 521 568 By similarity.
DISULFID 525 542 By similarity.
Amino Acid Sequence for SEM6A_HUMAN » Semaphorin-6A
MRSEALLLYF TLLHFAGAGF PEDSEPISIS HGNYTKQYPV FVGHKPGRNT TQRHRLDIQM IMIMNGTLYI AARDHIYTVD IDTSHTEEIY CSKKLTWKSR QADVDTCRMK GKHKDECHNF IKVLLKKNDD ALFVCGTNAF NPSCRNYKMD TLEPFGDEFS GMARCPYDAK HANVALFADG KLYSATVTDF LAIDAVIYRS LGESPTLRTV KHDSKWLKEP YFVQAVDYGD YIYFFFREIA VEYNTMGKVV FPRVAQVCKN DMGGSQRVLE KQWTSFLKAR LNCSVPGDSH FYFNILQAVT DVIRINGRDV VLATFSTPYN SIPGSAVCAY DMLDIASVFT GRFKEQKSPD STWTPVPDER VPKPRPGCCA GSSSLERYAT SNEFPDDTLN FIKTHPLMDE AVPSIFNRPW FLRTMVRYRL TKIAVDTAAG PYQNHTVVFL GSEKGIILKF LARIGNSGFL NDSLFLEEMS VYNSEKCSYD GVEDKRIMGM QLDRASSSLY VAFSTCVIKV PLGRCERHGK CKKTCIASRD PYCGWIKEGG ACSHLSPNSR LTFEQDIERG NTDGLGDCHN SFVALNGHSS SLLPSTTTSD STAQEGYESR GGMLDWKHLL DSPDSTDPLG AVSSHNHQDK KGVIRESYLK GHDQLVPVTL LAIAVILAFV MGAVFSGITV YCVCDHRRKD VAVVQRKEKE LTHSRRGSMS SVTKLSGLFG DTQSKDPKPE AILTPLMHNG KLATPGNTAK MLIKADQHHL DLTALPTPES TPTLQQKRKP SRGSREWERN QNLINACTKD MPPMGSPVIP TDLPLRASPS HIPSVVVLPI TQQGYQHEYV DQPKMSEVAQ MALEDQAATL EYKTIKEHLS SKSPNHGVNL VENLDSLPPK VPQREASLGP PGASLSQTGL SKRLEMHHSS SYGVDYKRSY PTNSLTRSHQ ATTLKRNNTN SSNSSHLSRN QSFGRGDNPP PAPQRVDSIQ VHSSQPSGQA VTVSRQPSLN AYNSLTRSGL KRTPSLKPDV PPKPSFAPLS TSMKPNDACT