SEM5B_HUMAN » Semaphorin-5B

SEM5B_HUMAN » Semaphorin-5B
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM5B_HUMAN » Semaphorin-5B »
Hydrophobic Thickness 28.8 ± 2.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -31.3 kcal/mol
ΔGfold -8.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1034-1059 (1034-1060)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 128-534, PDBID: 1OLZ, Subunit B, Seq Identity:37%, Sema domain

AA: 555-602, PDBID: 3NVN, Subunit B, Seq Identity:35%, Plexin repeat

AA: 668-719, PDBID: 1LSL, Subunit A, Seq Identity:47%, Thrombospondin type 1 domain

AA: 726-770, PDBID: 4DLO, Subunit B, Seq Identity:43%, Thrombospondin type 1 domain

AA: 857-907, PDBID: 1LSL, Subunit A, Seq Identity:49%, Thrombospondin type 1 domain

AA: 914-966, PDBID: 3GHM, Subunit A, Seq Identity:46%, Thrombospondin type 1 domain

AA: 969-1013, PDBID: 5FOE, Subunit B, Seq Identity:37%, Thrombospondin type 1 domain

UniProt annotation for SEM5B_HUMAN » Semaphorin-5B
FUNCTION: May act as positive axonal guidance cues.
UniProt features for SEM5B_HUMAN » Semaphorin-5B
CHAIN 1 1151 Semaphorin-5B.
DOMAIN 103 553 Sema.
DOMAIN 664 720 TSP type-1 1.
DOMAIN 722 771 TSP type-1 2.
DOMAIN 853 908 TSP type-1 3.
DOMAIN 910 965 TSP type-1 4.
DOMAIN 966 1010 TSP type-1 5.
DISULFID 172 182 By similarity.
DISULFID 199 208 By similarity.
DISULFID 322 425 By similarity.
DISULFID 346 388 By similarity.
DISULFID 556 573 By similarity.
DISULFID 565 582 By similarity.
DISULFID 676 713 By similarity.
DISULFID 680 719 By similarity.
DISULFID 691 703 By similarity.
DISULFID 734 765 By similarity.
DISULFID 738 770 By similarity.
DISULFID 749 755 By similarity.
DISULFID 865 902 By similarity.
DISULFID 869 907 By similarity.
DISULFID 880 892 By similarity.
DISULFID 922 959 By similarity.
DISULFID 926 964 By similarity.
DISULFID 937 949 By similarity.
Amino Acid Sequence for SEM5B_HUMAN » Semaphorin-5B
MPCGFSPSPV AHHLVPGPPD TPAQQLRCGW TVGGWLLSLV RGLLPCLPPG ARTAEGPIMV LAGPLAVSLL LPSLTLLVSH LSSSQDVSSE PSSEQQLCAL SKHPTVAFED LQPWVSNFTY PGARDFSQLA LDPSGNQLIV GARNYLFRLS LANVSLLQAT EWASSEDTRR SCQSKGKTEE ECQNYVRVLI VAGRKVFMCG TNAFSPMCTS RQVGNLSRTI EKINGVARCP YDPRHNSTAV ISSQGELYAA TVIDFSGRDP AIYRSLGSGP PLRTAQYNSK WLNEPNFVAA YDIGLFAYFF LRENAVEHDC GRTVYSRVAR VCKNDVGGRF LLEDTWTTFM KARLNCSRPG EVPFYYNELQ SAFHLPEQDL IYGVFTTNVN SIAASAVCAF NLSAISQAFN GPFRYQENPR AAWLPIANPI PNFQCGTLPE TGPNENLTER SLQDAQRLFL MSEAVQPVTP EPCVTQDSVR FSHLVVDLVQ AKDTLYHVLY IGTESGTILK ALSTASRSLH GCYLEELHVL PPGRREPLRS LRILHSARAL FVGLRDGVLR VPLERCAAYR SQGACLGARD PYCGWDGKQQ RCSTLEDSSN MSLWTQNITA CPVRNVTRDG GFGPWSPWQP CEHLDGDNSG SCLCRARSCD SPRPRCGGLD CLGPAIHIAN CSRNGAWTPW SSWALCSTSC GIGFQVRQRS CSNPAPRHGG RICVGKSREE RFCNENTPCP VPIFWASWGS WSKCSSNCGG GMQSRRRACE NGNSCLGCGV EFKTCNPEGC PEVRRNTPWT PWLPVNVTQG GARQEQRFRF TCRAPLADPH GLQFGRRRTE TRTCPADGSG SCDTDALVEV LLRSGSTSPH TVSGGWAAWG PWSSCSRDCE LGFRVRKRTC TNPEPRNGGL PCVGDAAEYQ DCNPQACPVR GAWSCWTSWS PCSASCGGGH YQRTRSCTSP APSPGEDICL GLHTEEALCA TQACPEGWSP WSEWSKCTDD GAQSRSRHCE ELLPGSSACA GNSSQSRPCP YSEIPVILPA SSMEEATDCA GFNLIHLVAT GISCFLGSGL LTLAVYLSCQ HCQRQSQEST LVHPATPNHL HYKGGGTPKN EKYTPMEFKT LNKNNLIPDD RANFYPLQQT NVYTTTYYPS PLNKHSFRPE ASPGQRCFPN S