SEM5A_HUMAN » Semaphorin-5A

SEM5A_HUMAN » Semaphorin-5A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM5A_HUMAN » Semaphorin-5A » Semaphorin-F;Sema F;
Hydrophobic Thickness 34.4 ± 1.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -33.3 kcal/mol
ΔGfold -13.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 968-993 (968-996)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 60-465, PDBID: 3AFC, Subunit B, Seq Identity:40%, Sema domain

AA: 599-650, PDBID: 1LSL, Subunit A, Seq Identity:47%, Thrombospondin type 1 domain

AA: 657-701, PDBID: 1LSL, Subunit A, Seq Identity:41%, Thrombospondin type 1 domain

AA: 788-838, PDBID: 3GHM, Subunit A, Seq Identity:46%, Thrombospondin type 1 domain

AA: 845-895, PDBID: 1LSL, Subunit A, Seq Identity:53%, Thrombospondin type 1 domain

AA: 900-944, PDBID: 3OJY, Subunit B, Seq Identity:38%, Thrombospondin type 1 domain

UniProt annotation for SEM5A_HUMAN » Semaphorin-5A
FUNCTION: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.

SUBUNIT: Binds PLXNB3.

UniProt features for SEM5A_HUMAN » Semaphorin-5A
SIGNAL 1 22 Potential.
CHAIN 23 1074 Semaphorin-5A.
DOMAIN 35 484 Sema.
DOMAIN 540 593 TSP type-1 1.
DOMAIN 595 651 TSP type-1 2.
DOMAIN 653 702 TSP type-1 3.
DOMAIN 707 765 TSP type-1 4.
DOMAIN 784 839 TSP type-1 5.
DOMAIN 841 896 TSP type-1 6.
DOMAIN 897 944 TSP type-1 7.
DISULFID 104 114 By similarity.
DISULFID 131 140 By similarity.
DISULFID 254 357 By similarity.
DISULFID 278 320 By similarity.
DISULFID 487 504 By similarity.
DISULFID 496 513 By similarity.
DISULFID 607 644 By similarity.
DISULFID 611 650 By similarity.
DISULFID 622 634 By similarity.
DISULFID 665 696 By similarity.
DISULFID 669 701 By similarity.
DISULFID 680 686 By similarity.
DISULFID 796 833 By similarity.
DISULFID 800 838 By similarity.
DISULFID 811 823 By similarity.
DISULFID 853 890 By similarity.
DISULFID 857 895 By similarity.
DISULFID 868 880 By similarity.
Amino Acid Sequence for SEM5A_HUMAN » Semaphorin-5A
MKGTCVIAWL FSSLGLWRLA HPEAQGTTQC QRTEHPVISY KEIGPWLREF RAKNAVDFSQ LTFDPGQKEL VVGARNYLFR LQLEDLSLIQ AVEWECDEAT KKACYSKGKS KEECQNYIRV LLVGGDRLFT CGTNAFTPVC TNRSLSNLTE IHDQISGMAR CPYSPQHNST ALLTAGGELY AATAMDFPGR DPAIYRSLGI LPPLRTAQYN SKWLNEPNFV SSYDIGNFTY FFFRENAVEH DCGKTVFSRA ARVCKNDIGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE LQSTFFLPEL DLIYGIFTTN VNSIAASAVC VFNLSAIAQA FSGPFKYQEN SRSAWLPYPN PNPHFQCGTV DQGLYVNLTE RNLQDAQKFI LMHEVVQPVT TVPSFMEDNS RFSHVAVDVV QGREALVHII YLATDYGTIK KVRVPLNQTS SSCLLEEIEL FPERRREPIR SLQILHSQSV LFVGLREHVV KIPLKRCQFY RTRSTCIGAQ DPYCGWDVVM KKCTSLEESL SMTQWEQSIS ACPTRNLTVD GHFGVWSPWT PCTHTDGSAV GSCLCRTRSC DSPAPQCGGW QCEGPGMEIA NCSRNGGWTP WTSWSPCSTT CGIGFQVRQR SCSNPTPRHG GRVCVGQNRE ERYCNEHLLC PPHMFWTGWG PWERCTAQCG GGIQARRRIC ENGPDCAGCN VEYQSCNTNP CPELKKTTPW TPWTPVNISD NGGHYEQRFR YTCKARLADP NLLEVGRQRI EMRYCSSDGT SGCSTDGLSG DFLRAGRYSA HTVNGAWSAW TSWSQCSRDC SRGIRNRKRV CNNPEPKYGG MPCLGPSLEY QECNILPCPV DGVWSCWSPW TKCSATCGGG HYMRTRSCSN PAPAYGGDIC LGLHTEEALC NTQPCPESWS EWSDWSECEA SGVQVRARQC ILLFPMGSQC SGNTTESRPC VFDSNFIPEV SVARSSSVEE KRCGEFNMFH MIAVGLSSSI LGCLLTLLVY TYCQRYQQQS HDATVIHPVS PAPLNTSITN HINKLDKYDS VEAIKAFNKN NLILEERNKY FNPHLTGKTY SNAYFTDLNN YDEY