SEM4G_HUMAN » Semaphorin-4G

SEM4G_HUMAN » Semaphorin-4G
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM4G_HUMAN » Semaphorin-4G »
Hydrophobic Thickness 34.4 ± 1.8 Å
Tilt Angle 43 ± 0°
ΔGtransfer -24.3 kcal/mol
ΔGfold -19.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 671-700 (671-706)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 58-486, PDBID: 1OLZ, Subunit B, Seq Identity:45%, Sema domain

AA: 507-560, PDBID: 3AFC, Subunit B, Seq Identity:42%, Plexin repeat

UniProt annotation for SEM4G_HUMAN » Semaphorin-4G
FUNCTION: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

SUBUNIT: Interacts with PLXNB2.

UniProt features for SEM4G_HUMAN » Semaphorin-4G
SIGNAL 1 17 Potential.
CHAIN 18 838 Semaphorin-4G.
DOMAIN 35 505 Sema.
DOMAIN 507 558 PSI.
DOMAIN 567 649 Ig-like C2-type.
DISULFID 104 115 By similarity.
DISULFID 133 142 By similarity.
DISULFID 270 377 By similarity.
DISULFID 294 337 By similarity.
DISULFID 508 525 By similarity.
DISULFID 517 534 By similarity.
DISULFID 584 632 By similarity.
Amino Acid Sequence for SEM4G_HUMAN » Semaphorin-4G
MWGRLWPLLL SILTATAVPG PSLRRPSREL DATPRMTIPY EELSGTRHFK GQAQNYSTLL LEEASARLLV GARGALFSLS ANDIGDGAHK EIHWEASPEM QSKCHQKGKN NQTECFNHVR FLQRLNSTHL YACGTHAFQP LCAAIDAEAF TLPTSFEEGK EKCPYDPARG FTGLIIDGGL YTATRYEFRS IPDIRRSRHP HSLRTEETPM HWLNDAEFVF SVLVRESKAS AVGDDDKVYY FFTERATEEG SGSFTQSRSS HRVARVARVC KGDLGGKKIL QKKWTSFLKA RLICHIPLYE TLRGVCSLDA ETSSRTHFYA AFTLSTQWKT LEASAICRYD LAEIQAVFAG PYMEYQDGSR RWGRYEGGVP EPRPGSCITD SLRSQGYNSS QDLPSLVLDF VKLHPLMARP VVPTRGRPLL LKRNIRYTHL TGTPVTTPAG PTYDLLFLGT ADGWIHKAVV LGSGMHIIEE TQVFRESQSV ENLVISLLQH SLYVGAPSGV IQLPLSSCSR YRSCYDCILA RDPYCGWDPG THACAAATTI ANRTALIQDI ERGNRGCESS RDTGPPPPLK TRSVLRGDDV LLPCDQPSNL ARALWLLNGS MGLSDGQGGY RVGVDGLLVT DAQPEHSGNY GCYAEENGLR TLLASYSLTV RPATPAPAPK APATPGAQLA PDVRLLYVLA IAALGGLCLI LASSLLYVAC LREGRRGRRR KYSLGRASRA GGSAVQLQTV SGQCPGEEDE GDDEGAGGLE GSCLQIIPGE GAPAPPPPPP PPPPAELTNG LVALPSRLRR MNGNSYVLLR QSNNGVPAGP CSFAEELSRI LEKRKHTQLV EQLDESSV