SEM4F_HUMAN » Semaphorin-4F

SEM4F_HUMAN » Semaphorin-4F
Magnify SEM4F_HUMAN » Semaphorin-4FEnlarged view of image
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM4F_HUMAN » Semaphorin-4F » Semaphorin-M;Sema M; Semaphorin-W;Sema W;
Hydrophobic Thickness 37.6 ± 2.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -40.6 kcal/mol
ΔGfold -16.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 658-682 (651-687)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions

NRP2, Complex: NRP2:SEM4F, PubMed

Domains

AA: 67-493, PDBID: 1OLZ, Subunit B, Seq Identity:40%, Sema domain

AA: 512-563, PDBID: 3AFC, Subunit B, Seq Identity:38%, Plexin repeat

UniProt annotation for SEM4F_HUMAN » Semaphorin-4F
FUNCTION: Has growth cone collapse activity against retinal ganglion-cell axons.
UniProt features for SEM4F_HUMAN » Semaphorin-4F
SIGNAL 1 34 Potential.
CHAIN 35 770 Semaphorin-4F.
DOMAIN 42 510 Sema.
DOMAIN 512 563 PSI.
DOMAIN 580 635 Ig-like C2-type.
DISULFID 112 122 By similarity.
DISULFID 140 149 By similarity.
DISULFID 273 384 By similarity.
DISULFID 297 343 By similarity.
DISULFID 513 530 By similarity.
DISULFID 522 539 By similarity.
DISULFID 587 628 By similarity.
Amino Acid Sequence for SEM4F_HUMAN » Semaphorin-4F
MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA DSCLTRFAVP HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI DWMVPEAHRQ NCRKKGKKED ECHNFVQILA IANASHLLTC GTFAFDPKCG VIDVSRFQQV ERLESGRGKC PFEPAQRSAA VMAGGVLYAA TVKNYLGTEP IITRAVGRAE DWIRTDTLPS WLNAPAFVAA VALSPAEWGD EDGDDEIYFF FTETSRAFDS YERIKVPRVA RVCAGDLGGR KTLQQRWTTF LKADLLCPGP EHGRASSVLQ DVAVLRPELG AGTPIFYGIF SSQWEGATIS AVCAFRPQDI RTVLNGPFRE LKHDCNRGLP VVDNDVPQPR PGECITNNMK LRHFGSSLSL PDRVLTFIRD HPLMDRPVFP ADGHPLLVTT DTAYLRVVAH RVTSLSGKEY DVLYLGTEDG HLHRAVRIGA QLSVLEDLAL FPEPQPVENM KLYHSWLLVG SRTEVTQVNT TNCGRLQSCS ECILAQDPVC AWSFRLDECV AHAGEHRGLV QDIESADVSS LCPKEPGERP VVFEVPVATA AHVVLPCSPS SAWASCVWHQ PSGVTALTPR RDGLEVVVTP GAMGAYACEC QEGGAAHVVA AYSLVWGSQR DAPSRAHTVG AGLAGFFLGI LAASLTLILI GRRQQRRRQR ELLARDKVGL DLGAPPSGTT SYSQDPPSPS PEDERLPLAL AKRGSGFGGF SPPFLLDPCP SPAHIRLTGA PLATCDETSI