SEM4D_HUMAN » Semaphorin-4D

SEM4D_HUMAN » Semaphorin-4D
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM4D_HUMAN » Semaphorin-4D » A8;BB18;GR3;
Hydrophobic Thickness 30.8 ± 2.0 Å
Tilt Angle 1 ± 0°
ΔGtransfer -43.0 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 733-754 (731-756)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB 1olz (A/B=22-677), 3ol2 (A=22-677)
OPM none
Complexes

SEM4D:PLXB1_HUMAN

SEM4D:SEM4D_HUMAN

Interactions

CD72, Complex: CD72:SEM4D, PubMed

PLXB1, Complex: SEM4D:PLXB1, PDBID: 3ol2, PubMed

PTPRC, Complex: SEM4D:PTPRC, PubMed

SEM4D, Complex: Homodimer of semaphorin-4D, PDBID: 1OLZ

Domains

AA: 52-479, PDBID: 1OLZ, Subunit B, Seq Identity:100%, Sema domain

AA: 502-554, PDBID: 1OLZ, Subunit B, Seq Identity:100%, Plexin repeat

AA: 561-639, PDBID: 1OLZ, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for SEM4D_HUMAN » Semaphorin-4D
FUNCTION: Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

SUBUNIT: Homodimer. Interacts with PLXNB2 (By similarity). Binds PLXNB1.

TISSUE SPECIFICITY: Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.

UniProt features for SEM4D_HUMAN » Semaphorin-4D
SIGNAL 1 21 Potential.
CHAIN 22 862 Semaphorin-4D.
DOMAIN 22 500 Sema.
DOMAIN 502 551 PSI.
DOMAIN 554 636 Ig-like C2-type.
DISULFID 97 108
DISULFID 126 135
DISULFID 257 370
DISULFID 281 326
DISULFID 503 520
DISULFID 509 553
DISULFID 512 529
DISULFID 576 624
Amino Acid Sequence for SEM4D_HUMAN » Semaphorin-4D
MRMCTPIRGL LMALAVMFGT AMAFAPIPRI TWEHREVHLV QFHEPDIYNY SALLLSEDKD TLYIGAREAV FAVNALNISE KQHEVYWKVS EDKKAKCAEK GKSKQTECLN YIRVLQPLSA TSLYVCGTNA FQPACDHLNL TSFKFLGKNE DGKGRCPFDP AHSYTSVMVD GELYSGTSYN FLGSEPIISR NSSHSPLRTE YAIPWLNEPS FVFADVIRKS PDSPDGEDDR VYFFFTEVSV EYEFVFRVLI PRIARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSGLVF NVLRDVFVLR SPGLKVPVFY ALFTPQLNNV GLSAVCAYNL STAEEVFSHG KYMQSTTVEQ SHTKWVRYNG PVPKPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM DDSVTPIDNR PRLIKKDVNY TQIVVDRTQA LDGTVYDVMF VSTDRGALHK AISLEHAVHI IEETQLFQDF EPVQTLLLSS KKGNRFVYAG SNSGVVQAPL AFCGKHGTCE DCVLARDPYC AWSPPTATCV ALHQTESPSR GLIQEMSGDA SVCPDKSKGS YRQHFFKHGG TAELKCSQKS NLARVFWKFQ NGVLKAESPK YGLMGRKNLL IFNLSEGDSG VYQCLSEERV KNKTVFQVVA KHVLEVKVVP KPVVAPTLSV VQTEGSRIAT KVLVASTQGS SPPTPAVQAT SSGAITLPPK PAPTGTSCEP KIVINTVPQL HSEKTMYLKS SDNRLLMSLF LFFFVLFLCL FFYNCYKGYL PRQCLKFRSA LLIGKKKPKS DFCDREQSLK ETLVEPGSFS QQNGEHPKPA LDTGYETEQD TITSKVPTDR EDSQRIDDLS ARDKPFDVKC ELKFADSDAD GD