SEM4C_HUMAN » Semaphorin-4C

SEM4C_HUMAN » Semaphorin-4C
Magnify SEM4C_HUMAN » Semaphorin-4CEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM4C_HUMAN » Semaphorin-4C »
Hydrophobic Thickness 28.8 ± 1.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -41.3 kcal/mol
ΔGfold -27.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 662-687 (660-696)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 55-478, PDBID: 1OLZ, Subunit B, Seq Identity:50%, Sema domain

AA: 499-550, PDBID: 3AFC, Subunit B, Seq Identity:40%, Plexin repeat

UniProt annotation for SEM4C_HUMAN » Semaphorin-4C
FUNCTION: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at "Tyr-1248". Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

SUBUNIT: Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).

UniProt features for SEM4C_HUMAN » Semaphorin-4C
SIGNAL 1 20 Potential.
CHAIN 21 833 Semaphorin-4C.
DOMAIN 30 497 Sema.
DOMAIN 499 551 PSI.
DOMAIN 556 644 Ig-like C2-type.
REGION 46 489 Dominant negative effect on myogenic differentiation (By similarity).
MOTIF 830 833 PDZ-binding.
DISULFID 99 110 By similarity.
DISULFID 128 137 By similarity.
DISULFID 261 370 By similarity.
DISULFID 285 330 By similarity.
DISULFID 500 517 By similarity.
DISULFID 509 526 By similarity.
Amino Acid Sequence for SEM4C_HUMAN » Semaphorin-4C
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV