SEM4B_HUMAN » Semaphorin-4B

SEM4B_HUMAN » Semaphorin-4B
Magnify SEM4B_HUMAN » Semaphorin-4BEnlarged view of image
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM4B_HUMAN » Semaphorin-4B »
Hydrophobic Thickness 34.4 ± 3.4 Å
Tilt Angle 29 ± 22°
ΔGtransfer -31.4 kcal/mol
ΔGfold -22.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 710-736 (705-739)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions

DCBD2, Complex: SEM4B:DCBD2, PubMed

PLXB1, Complex: PLXB1:SEM4B, PubMed

Domains

AA: 67-499, PDBID: 1OLZ, Subunit B, Seq Identity:47%, Sema domain

AA: 520-574, PDBID: 1SHY, Subunit B, Seq Identity:26%, Plexin repeat

UniProt annotation for SEM4B_HUMAN » Semaphorin-4B
FUNCTION: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
UniProt features for SEM4B_HUMAN » Semaphorin-4B
SIGNAL 1 38
CHAIN 39 832 Semaphorin-4B.
DOMAIN 42 518 Sema.
DOMAIN 520 574 PSI.
DOMAIN 599 658 Ig-like C2-type.
DISULFID 115 126 By similarity.
DISULFID 144 153 By similarity.
DISULFID 281 394 By similarity.
DISULFID 305 354 By similarity.
DISULFID 521 538 By similarity.
DISULFID 606 651 By similarity.
Amino Acid Sequence for SEM4B_HUMAN » Semaphorin-4B
MGLRSWLAAP WGALPPRPPL LLLLLLLLLL QPPPPTWALS PRISLPLGSE ERPFLRFEAE HISNYTALLL SRDGRTLYVG AREALFALSS NLSFLPGGEY QELLWGADAE KKQQCSFKGK DPQRDCQNYI KILLPLSGSH LFTCGTAAFS PMCTYINMEN FTLARDEKGN VLLEDGKGRC PFDPNFKSTA LVVDGELYTG TVSSFQGNDP AISRSQSLRP TKTESSLNWL QDPAFVASAY IPESLGSLQG DDDKIYFFFS ETGQEFEFFE NTIVSRIARI CKGDEGGERV LQQRWTSFLK AQLLCSRPDD GFPFNVLQDV FTLSPSPQDW RDTLFYGVFT SQWHRGTTEG SAVCVFTMKD VQRVFSGLYK EVNRETQQWY TVTHPVPTPR PGACITNSAR ERKINSSLQL PDRVLNFLKD HFLMDGQVRS RMLLLQPQAR YQRVAVHRVP GLHHTYDVLF LGTGDGRLHK AVSVGPRVHI IEELQIFSSG QPVQNLLLDT HRGLLYAASH SGVVQVPMAN CSLYRSCGDC LLARDPYCAW SGSSCKHVSL YQPQLATRPW IQDIEGASAK DLCSASSVVS PSFVPTGEKP CEQVQFQPNT VNTLACPLLS NLATRLWLRN GAPVNASASC HVLPTGDLLL VGTQQLGEFQ CWSLEEGFQQ LVASYCPEVV EDGVADQTDE GGSVPVIIST SRVSAPAGGK ASWGADRSYW KEFLVMCTLF VLAVLLPVLF LLYRHRNSMK VFLKQGECAS VHPKTCPVVL PPETRPLNGL GPPSTPLDHR GYQSLSDSPP GSRVFTESEK RPLSIQDSFV EVSPVCPRPR VRLGSEIRDS VV