SEM4A_HUMAN » Semaphorin-4A

SEM4A_HUMAN » Semaphorin-4A
Magnify SEM4A_HUMAN » Semaphorin-4AEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SEM4A_HUMAN » Semaphorin-4A » Semaphorin-B;Sema B;
Hydrophobic Thickness 34.8 ± 3.2 Å
Tilt Angle 23 ± 10°
ΔGtransfer -28.7 kcal/mol
ΔGfold -20.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 684-709 (680-713)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

HAVR1, Complex: HAVR1:SEM4A, PubMed

PLXB1, Complex: PLXB1:SEM4A, PubMed

PLXB2, Complex: SEM4A:PLXB2, PubMed

PLXB3, Complex: PLXB3:SEM4A, PubMed

PLXD1, Complex: SEM4A:PLXD1, PubMed

Domains

AA: 66-475, PDBID: 1OLZ, Subunit B, Seq Identity:46%, Sema domain

AA: 496-548, PDBID: 1OLZ, Subunit B, Seq Identity:27%, Plexin repeat

UniProt annotation for SEM4A_HUMAN » Semaphorin-4A
FUNCTION: Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).

SUBUNIT: Interacts with PLXNB1, PLXNB2, PLXNB3 and PLXND1. Probable ligand for TIMD2 (By similarity).

DISEASE: Retinitis pigmentosa 35 (RP35) OMIM: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. caused by mutations affecting the gene represented in this entry.

DISEASE: Cone-rod dystrophy 10 (CORD10) OMIM: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. disease is caused by mutations affecting the gene represented in this entry.

UniProt features for SEM4A_HUMAN » Semaphorin-4A
SIGNAL 1 32 Potential.
CHAIN 33 761 Semaphorin-4A.
DOMAIN 36 494 Sema.
DOMAIN 496 548 PSI.
DOMAIN 573 631 Ig-like C2-type.
DISULFID 113 124 By similarity.
DISULFID 142 151 By similarity.
DISULFID 269 379 By similarity.
DISULFID 293 339 By similarity.
DISULFID 497 514 By similarity.
DISULFID 506 523 By similarity.
DISULFID 580 624 By similarity.
Amino Acid Sequence for SEM4A_HUMAN » Semaphorin-4A
MALPALGLDP WSLLGLFLFQ LLQLLLPTTT AGGGGQGPMP RVRYYAGDER RALSFFHQKG LQDFDTLLLS GDGNTLYVGA REAILALDIQ DPGVPRLKNM IPWPASDRKK SECAFKKKSN ETQCFNFIRV LVSYNVTHLY TCGTFAFSPA CTFIELQDSY LLPISEDKVM EGKGQSPFDP AHKHTAVLVD GMLYSGTMNN FLGSEPILMR TLGSQPVLKT DNFLRWLHHD ASFVAAIPST QVVYFFFEET ASEFDFFERL HTSRVARVCK NDVGGEKLLQ KKWTTFLKAQ LLCTQPGQLP FNVIRHAVLL PADSPTAPHI YAVFTSQWQV GGTRSSAVCA FSLLDIERVF KGKYKELNKE TSRWTTYRGP ETNPRPGSCS VGPSSDKALT FMKDHFLMDE QVVGTPLLVK SGVEYTRLAV ETAQGLDGHS HLVMYLGTTT GSLHKAVVSG DSSAHLVEEI QLFPDPEPVR NLQLAPTQGA VFVGFSGGVW RVPRANCSVY ESCVDCVLAR DPHCAWDPES RTCCLLSAPN LNSWKQDMER GNPEWACASG PMSRSLRPQS RPQIIKEVLA VPNSILELPC PHLSALASYY WSHGPAAVPE ASSTVYNGSL LLIVQDGVGG LYQCWATENG FSYPVISYWV DSQDQTLALD PELAGIPREH VKVPLTRVSG GAALAAQQSY WPHFVTVTVL FALVLSGALI ILVASPLRAL RARGKVQGCE TLRPGEKAPL SREQHLQSPK ECRTSASDVD ADNNCLGTEV A