SELS_HUMAN » Selenoprotein S

SELS_HUMAN » Selenoprotein S
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SELS_HUMAN » Selenoprotein S » SelS; VCP-interacting membrane protein;
Hydrophobic Thickness 28.4 ± 2.5 Å
Tilt Angle 30 ± 1°
ΔGtransfer -17.0 kcal/mol
ΔGfold -12.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 34-55 (28-58)
Pathways

Protein processing in endoplasmic reticulum (KEGG)

PDB 2q2f (A=52-122)
OPM none
Complexes none
Interactions

SE1L1, Complex: DERL1:TERA:SELS:SE1L1:SYVN1:DERL2

Domains

AA: 1-187, PDBID: 2Q2F, Subunit A, Seq Identity:100%, Selenoprotein S (SelS)

UniProt annotation for SELS_HUMAN » Selenoprotein S
FUNCTION: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

SUBUNIT: Interacts with DERL1 and (via VIM motif) with VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Also interacts with DERL2, DERL3 and SELK. The SELK-VIMP complex interacts with VCP. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP.

UniProt features for SELS_HUMAN » Selenoprotein S
CHAIN 1 189 Selenoprotein S.
NON_STD 188 188 Selenocysteine.
Amino Acid Sequence for SELS_HUMAN » Selenoprotein S
MERQEESLSA RPALETEGLR FLHTTVGSLL ATYGWYIVFS CILLYVVFQK LSARLRALRQ RQLDRAAAAV EPDVVVKRQE ALAAARLKMQ EELNAQVEKH KEKLKQLEEE KRRQKIEMWD SMQEGKSYKG NAKKPQEEDS PGPSTSSVLK RKSDRKPLRG GGYNPLSGEG GGACSWRPGR RGPSSGGUG