SELPL_HUMAN » P-selectin glycoprotein ligand 1

SELPL_HUMAN » P-selectin glycoprotein ligand 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SELPL_HUMAN » P-selectin glycoprotein ligand 1 » PSGL-1; Selectin P ligand;
Hydrophobic Thickness 35.6 ± 4.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -47.9 kcal/mol
ΔGfold -27.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 317-345 (312-348)
Pathways

Cell adhesion molecules (KEGG)

Hemostasis (Reactome)

Staphylococcus aureus infection (KEGG)

PDB 1g1s (C/D=42-60)
OPM none
Complexes

SELPL:LYAM3_HUMAN

Interactions

ADAM8, Complex: SELPL:ADAM8, PubMed

BACE1, Complex: BACE1:SELPL, PubMed

GALT4, Complex: SELPL:GALT4, PubMed

LYAM1, Complex: LYAM1:SELPL, PubMed

LYAM2, Complex: SELPL:LYAM2, PubMed

LYAM3, Complex: LYAM3:SELPL, PDBID: 1g1s, PubMed

TPST1, Complex: SELPL:TPST1, PubMed

TPST2, Complex: TPST2:SELPL, PubMed

Domains none
UniProt annotation for SELPL_HUMAN » P-selectin glycoprotein ligand 1
FUNCTION: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.

SUBUNIT: Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is most important for high affinity L- selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48. E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparantly not tyrosine sulfation. Dimerization appears not to be required for P- selectin/SELP binding. Interacts with SNX20. Interacts with MSN and SYK; mediates the activation of SYK by SELPLG.

TISSUE SPECIFICITY: Expressed on neutrophils, monocytes and most lymphocytes.

UniProt features for SELPL_HUMAN » P-selectin glycoprotein ligand 1
SIGNAL 1 17 Potential.
PROPEP 18 41
CHAIN 42 412 P-selectin glycoprotein ligand 1.
REPEAT 122 131 1.
REPEAT 132 141 2.
REPEAT 142 151 3.
REPEAT 162 171 4.
REPEAT 182 191 5.
REPEAT 192 201 6.
REPEAT 202 211 7.
REPEAT 212 221 8.
REPEAT 222 231 9.
REPEAT 232 241 10.
REPEAT 242 251 11.
REPEAT 252 261 12.
REGION 122 261 12 X 10 AA tandem repeats.
DISULFID 320 320 Interchain.
Amino Acid Sequence for SELPL_HUMAN » P-selectin glycoprotein ligand 1
MPLQLLLLLI LLGPGNSLQL WDTWADEAEK ALGPLLARDR RQATEYEYLD YDFLPETEPP EMLRNSTDTT PLTGPGTPES TTVEPAARRS TGLDAGGAVT ELTTELANMG NLSTDSAAME IQTTQPAATE AQTTQPVPTE AQTTPLAATE AQTTRLTATE AQTTPLAATE AQTTPPAATE AQTTQPTGLE AQTTAPAAME AQTTAPAAME AQTTPPAAME AQTTQTTAME AQTTAPEATE AQTTQPTATE AQTTPLAAME ALSTEPSATE ALSMEPTTKR GLFIPFSVSS VTHKGIPMAA SNLSVNYPVG APDHISVKQC LLAILILALV ATIFFVCTVV LAVRLSRKGH MYPVRNYSPT EMVCISSLLP DGGEGPSATA NGGLSKAKSP GLTPEPREDR EGDDLTLHSF LP