SED5_YEAST » Integral membrane protein SED5

SED5_YEAST » Integral membrane protein SED5
Magnify SED5_YEAST » Integral membrane protein SED5Enlarged view of image
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
SED5_YEAST » Integral membrane protein SED5 »
Hydrophobic Thickness 26.8 ± 2.6 Å
Tilt Angle 3 ± 0°
ΔGtransfer -35.8 kcal/mol
ΔGfold -16.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 320-339 (318-340)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB 1mqs (B=1-45), 1pd0 (B=201-210)
OPM none
Complexes none
Interactions

ANP1, Complex: SED5:ANP1, PubMed

ATG27, Complex: SED5:ATG27, PubMed

BET1, Complex: SED5:BET1, PubMed

BOS1, Complex: SED5:BOS1, PubMed

EMP24, Complex: SED5:EMP24, PubMed

EMP47, Complex: SED5:EMP47, PubMed

ERP1, Complex: SED5:ERP1, PubMed

ERP2, Complex: SED5:ERP2, PubMed

ERP3, Complex: ERP3:SED5

GOSR1, Complex: SED5:GOSR1, PubMed

HOC1, Complex: SED5:HOC1, PubMed

KEX2, Complex: SED5:KEX2, PubMed

KRE2, Complex: SED5:KRE2, PubMed

KTR1, Complex: SED5:KTR1, PubMed

KTR3, Complex: SED5:KTR3, PubMed

KTR4, Complex: SED5:KTR4, PubMed

MNN10, Complex: SED5:MNN10, PubMed

MNN11, Complex: SED5:MNN11, PubMed

MNN2, Complex: SED5:MNN2, PubMed

MNN9, Complex: SED5:MNN9, PubMed

NYV1, Complex: SED5:NYV1, PubMed

PEP12, Complex: SED5:PEP12, PubMed

SEC22, Complex: SED5:SEC22, PubMed

SEC66, Complex: SED5:SEC66, PubMed

SFT1, Complex: SED5:SFT1, PubMed

SNC2, Complex: SED5:SNC2, PubMed

TLG1, Complex: SED5:TLG1, PubMed

TLG2, Complex: SED5:TLG2

TMEDA, Complex: SED5:TMEDA, PubMed

UFE1, Complex: UFE1:SED5

USE1, Complex: SED5:USE1

VAN1, Complex: SED5:VAN1, PubMed

VTI1, Complex: SED5:VTI1, PubMed

Domains

AA: 1-20, PDBID: 1MQS, Subunit B, Seq Identity:100%, Syntaxin-5 N-terminal, Sly1p-binding domain

AA: 285-337, PDBID: 5BUZ, Subunit C, Seq Identity:29%, SNARE domain

UniProt annotation for SED5_YEAST » Integral membrane protein SED5
FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE).

SUBUNIT: Interacts with SLY1, STF1, SFB3 and GOS1.

MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.

UniProt features for SED5_YEAST » Integral membrane protein SED5
CHAIN 1 340 Integral membrane protein SED5.
DOMAIN 249 311 t-SNARE coiled-coil homology.
COILED 146 173 Potential.
Amino Acid Sequence for SED5_YEAST » Integral membrane protein SED5
MNIKDRTSEF QQSVLSYKKR NKNFREQQRE RLQEKESENF ANNTTGNGKS VSEFQKKASG IAHEISSTAQ LLSKLAVLAK RKPMFNDNPV EIAELSFLIK RKIYAIEQSL VQLSQLKKTD VNGNTSNQSS KQPSAVQHSK NVVNLLNTQM KNISGSFKDV LEERQRLEMA NKDRWQKLTT DTGHAPADDQ TQSNHAADLT TYNNSNPFMT SLLDESSEKN NNSSNQGELS FPQNDSQLML MEEGQLSNNV YLQERNRAVE TIESTIQEVG NLFQQLASMV QEQGEVIQRI DANVDDIDLN ISGAQRELLK YFDRIKSNRW LAAKVFFIIF VFFVIWVLVN