SED4_YEAST » Putative guanine nucleotide-exchange factor SED4

SED4_YEAST » Putative guanine nucleotide-exchange factor SED4
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SED4_YEAST » Putative guanine nucleotide-exchange factor SED4 »
Hydrophobic Thickness 29.4 ± 2.3 Å
Tilt Angle 35 ± 0°
ΔGtransfer -21.7 kcal/mol
ΔGfold -16.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 343-365 (338-366)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ANP1, Complex: SED4:ANP1

BOS1, Complex: BOS1:SED4

ERP1, Complex: ERP1:SED4

SEC12, Complex: SEC12:SED4

TMEDA, Complex: TMEDA:SED4

Domains

AA: 295-330, PDBID: 3SFZ, Subunit A, Seq Identity:42%, WD domain, G-beta repeat

UniProt annotation for SED4_YEAST » Putative guanine nucleotide-exchange factor SED4
FUNCTION: Putative guanine nucleotide-exchange factor (GEF) involved in the formation or budding of transport vesicles from the ER. Positive regulator of SAR1 probably through inhibition of the GTPase activation by SEC23.
UniProt features for SED4_YEAST » Putative guanine nucleotide-exchange factor SED4
CHAIN 1 1065 Putative guanine nucleotide-exchange factor SED4.
REPEAT 259 298 WD 1.
REPEAT 302 341 WD 2.
REPEAT 824 833 1.
REPEAT 834 843 2.
REPEAT 844 853 3.
REPEAT 854 863 4.
REGION 824 863 4 X 10 AA tandem repeats.
MOTIF 1062 1065 Prevents secretion from ER (Potential).
Amino Acid Sequence for SED4_YEAST » Putative guanine nucleotide-exchange factor SED4
MSGNSANYDV GYPIYGAKFI NEGTLLVAGG GGQFNSSFPN KITALKVNFQ KKKHIRRFRE ITLDSIDDAP TSLDCNNNLI LVGCNELFND SSMENVNHHL RKFVFEQEHL KFVASIDFNR TTDPSVFTKF VYINQRATVA AIASSEVPTV IRIIDPRNLT ENYEIETGRE VNDLHFAPNG ILLSYITSNS LEVASVRDGN FVARKTDFDK NLVLSNIRFL NDNTLLVAAS LSNSDGVSLL KLGVSSKGVK ILKTASFMFD LNGITSMDVS PNKKFVALSS NDNLVAIVSV EKLKLVQLVP RVHESTITKV TFSPDSRYLA STSMGNTINV LKLSGTSSSI LRNIWKFFLN FVLLVVLAGA IQLGYKHNVH GFIYKHAHDI YKSKFKENTT IDQGSSSYFT INDDYRGITE SADIISATDV ASDIETEFSS FDTSTMRTTT EDEQKFVWIS SSADSQFTSA DIPTSASSSS SSSSSSFYEE SVTNEPIVSS PTSEITKPLA SPTEPNIVEK PSLPLNSESI DLLSSSSNSI TEYPEPTPDL EEKLSSLIVE QSESEITTDR ESVSKLLSTE SPSLSHMPSS SSSSLSLSSS LTTSPTTALS TSTATAVTTT QTNPTNDAAN TSFLDNSKPA STREIYKTKI ITEVITKIEY RNIPASDSNA EAEQYVTTSS SMLLTPTDTM VSSPVSEIDP IASELERMVE TPTHSISIAS EFDSVASNLI PNEEILSTSA SQDSISSHPS TFSDSSITSG FQSIEVSTVT SSVLASESIP SISDSTFSKF HSISEPVSSA IVETATSSFS KTETKTSRVI AFSTEDSERS SALIDNSEYT SVLADNLEPT SVLADNSEPT SVLADSSEPT SVFTDAVQSP KTSVGQSSLS ESTNIEGTSM ASMIFSSSGA SIGALSDIGK GTLSVESASS TVAQPMPGVT TTAPSFVSSP HKISASSIDA SGFVQKEIMI EVQSSKDSSE AFGVRHKISE NVNTPVSRML TTEMQASGTV DVTEDVSLSS EVISALNVEI TSLPNPVAPP QTIAAPLNNN SNTNIVNDDN AVAGTVNYAG LHDEL