SEC66_YEAST » Translocation protein SEC66

SEC66_YEAST » Translocation protein SEC66
Magnify SEC66_YEAST » Translocation protein SEC66Enlarged view of image
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SEC66_YEAST » Translocation protein SEC66 » Protein HSS1;Sec62/63 complex 31.5 kDa subunit;
Hydrophobic Thickness 29.4 ± 3.4 Å
Tilt Angle 16 ± 13°
ΔGtransfer -18.6 kcal/mol
ΔGfold -18.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 31-51 (31-57)
Pathways none
PDB none
OPM none
Complexes none
Interactions

AIM34, Complex: SEC66:AIM34

ALG5, Complex: ALG5:SEC66, PubMed

ANP1, Complex: ANP1:SEC62:RL4A:SEC66:SEC72:MNN10:SEC63:FKS1, PubMed

BIG1, Complex: BIG1:SEC66

CALX, Complex: CALX:SEC66

CASP, Complex: CASP:SEC66

CSF1, Complex: CSF1:SEC66

ERP1, Complex: ERP1:SEC66

GDA1, Complex: GDA1:SEC66

GSF2, Complex: SEC66:GSF2

HLJ1, Complex: HLJ1:SEC66

HOC1, Complex: HOC1:SEC66

HPH1, Complex: SEC66:HPH1, PubMed

HPH2, Complex: SEC66:HPH2, PubMed

IRE1, Complex: IRE1:SEC66

KEX2, Complex: KEX2:SEC66

MGA2, Complex: SEC66:MGA2

MID2, Complex: MID2:SEC66

MNN10, Complex: ANP1:SEC62:RL4A:SEC66:SEC72:MNN10:SEC63:FKS1, PubMed

MNN11, Complex: MNN11:SEC66

MNN2, Complex: SEC66:MNN2

NEM1, Complex: NEM1:SEC66

OPY2, Complex: OPY2:SEC66

OST1, Complex: OST1:SEC66

OSTB, Complex: OSTB:SEC66

ROT1, Complex: SEC66:ROT1

SC61G, Complex: SC61A:SC61G:SEC62:SEC66:SEC72:SC6B1, PubMed

SC6B1, Complex: SC61A:SC61G:SEC62:SEC66:SEC72:SC6B1, PubMed

SCS2, Complex: SCS2:SEC66

SEC11, Complex: SEC11:SEC66

SEC22, Complex: SEC22:SEC66

SED5, Complex: SED5:SEC66, PubMed

SLP1, Complex: SLP1:SEC66

SNC2, Complex: SNC2:SEC66

SSO2, Complex: SSO2:SEC66

TLG2, Complex: TLG2:SEC66

TMEDA, Complex: TMEDA:SEC66

UBX2, Complex: SEC66:UBX2

VOA1, Complex: SEC66:VOA1

YND1, Complex: YND1:SEC66

YUR1, Complex: YUR1:SEC66

Domains

AA: 27-203, Preprotein translocase subunit Sec66

UniProt annotation for SEC66_YEAST » Translocation protein SEC66
FUNCTION: Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC66 is required to attach or retain SEC72 in the SEC63 complex. It is essential for growth at elevated temperatures.

SUBUNIT: Component of the heterotetrameric Sec62/63complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Part of a complex consisting of KAR2, SEC63, SEC66 and SEC72.

MISCELLANEOUS: Present with 7820 molecules/cell in log phase SD medium.

UniProt features for SEC66_YEAST » Translocation protein SEC66
CHAIN 1 206 Translocation protein SEC66.
Amino Acid Sequence for SEC66_YEAST » Translocation protein SEC66
MSEFNETKFS NNGTFFETEE PIVETKSISV YTPLIYVFIL VVSLVMFASS YRKKQAKKIS EQPSIFDEND AHDLYFQIKE MSENEKIHEK VLKAALLNRG AESVRRSLKL KELAPQINLL YKNGSIGEDY WKRFETEVKL IELEFKDTLQ EAERLQPGWV QLFVMVCKEI CFNQALSRRY QSILKRKEVC IKEWELKINN DGRLVN