SEC22_YEAST » Protein transport protein SEC22

SEC22_YEAST » Protein transport protein SEC22
Magnify SEC22_YEAST » Protein transport protein SEC22Enlarged view of image
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SEC22_YEAST » Protein transport protein SEC22 » Suppressor of loss of YPT1 protein 2;
Hydrophobic Thickness 32.4 ± 5.6 Å
Tilt Angle 29 ± 22°
ΔGtransfer -28.6 kcal/mol
ΔGfold -22.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 187-212 (187-213)
Pathways

Legionellosis (KEGG)

Phagosome (KEGG)

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

AIM34, Complex: SEC22:AIM34

ANP1, Complex: SEC22:ANP1, PubMed

BET1, Complex: SEC22:BET1, PubMed

BIG1, Complex: SEC22:BIG1

BOS1, Complex: SEC22:BOS1, PubMed

CSF1, Complex: SEC22:CSF1

EMP24, Complex: EMP24:SEC22

EMP47, Complex: SEC22:EMP47, PubMed

EPS1, Complex: SEC22:EPS1

ERP1, Complex: ERP1:SEC22

ERP2, Complex: ERP2:SEC22

FAR10, Complex: SEC22:FAR10

GOSR1, Complex: SEC22:GOSR1, PubMed

GSF2, Complex: SEC22:GSF2

HOC1, Complex: SEC22:HOC1

HRD3, Complex: HRD3:SEC22

IRE1, Complex: SEC22:IRE1

MGA2, Complex: SEC22:MGA2, PubMed

MMM1, Complex: SEC22:MMM1

MNN2, Complex: SEC22:MNN2, PubMed

MSMO, Complex: SEC22:MSMO

NYV1, Complex: SEC22:NYV1, PubMed

OSTB, Complex: SEC22:OSTB

PBN1, Complex: SEC22:PBN1, PubMed

PSD1, Complex: PSD1:SEC22

SC6B2, Complex: SC6B2:SEC22

SEC20, Complex: ADH1:G3P3:TIP20:SEC39:SEC22:DSL1:UFE1:USE1:SEC20, PubMed

SEC66, Complex: SEC22:SEC66

SED5, Complex: SED5:SEC22, PubMed

SFT1, Complex: SEC22:SFT1, PubMed

SNC2, Complex: SEC22:SNC2, PubMed

SSO1, Complex: SSO1:SEC22, PubMed

SSO2, Complex: SSO2:SEC22, PubMed

TLG1, Complex: TLG1:SEC22

TLG2, Complex: TLG2:SEC22

TMEDA, Complex: TMEDA:SEC22

TOM70, Complex: TOM70:SEC22

TSC3, Complex: TSC3:SEC22

UFE1, Complex: SEC22:UFE1, PubMed

UPPS, Complex: UPPS:SEC22

USE1, Complex: SEC22:USE1, PubMed

VAM3, Complex: SEC22:VAM3, PubMed

VOA1, Complex: SEC22:VOA1

VPS64, Complex: SEC22:VPS64

VTI1, Complex: SEC22:VTI1

Domains

AA: 34-115, PDBID: 1IFQ, Subunit B, Seq Identity:37%, Regulated-SNARE-like domain

AA: 129-214, PDBID: 1GL2, Subunit A, Seq Identity:30%, Synaptobrevin

UniProt annotation for SEC22_YEAST » Protein transport protein SEC22
FUNCTION: Nonessential SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

SUBUNIT: Component of two distinct SNARE complexes consisting of SED5, BOS1, BET1 and SEC22 or UFE1, USE1, SEC20 and SEC22. YKT6 can probably replace SEC22 as subunit of either complex. Interacts with SEC24, YIF1 and YIP1.

MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.

MISCELLANEOUS: Deletion of SEC22 is viable. Overexpression of SEC22 suppresses deletion of YPT1.

UniProt features for SEC22_YEAST » Protein transport protein SEC22
CHAIN 1 214 Protein transport protein SEC22.
DOMAIN 6 117 Longin.
DOMAIN 132 192 v-SNARE coiled-coil homology.
Amino Acid Sequence for SEC22_YEAST » Protein transport protein SEC22
MIKSTLIYRE DGLPLCTSVD NENDPSLFEQ KQKVKIVVSR LTPQSATEAT LESGSFEIHY LKKSMVYYFV ICESGYPRNL AFSYLNDIAQ EFEHSFANEY PKPTVRPYQF VNFDNFLQMT KKSYSDKKVQ DNLDQLNQEL VGVKQIMSKN IEDLLYRGDS LDKMSDMSSS LKETSKRYRK SAQKINFDLL ISQYAPIVIV AFFFVFLFWW IFLK